2012 Fiscal Year Final Research Report
Detection of HMGB1 in acetaminophen-induced liver injury model and its application for forensic diagnosis
| Project/Area Number |
23659370
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
ISHIDA Yuko 和歌山県立医科大学, 医学部, 講師 (10364077)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Toshikazu 和歌山県立医科大学, 医学部, 教授 (70251923)
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| Project Period (FY) |
2011 – 2012
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| Keywords | HMGB1 / アセトアミノフェン / 法医診断学 |
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| Research Abstract |
We examined HMGB1 expression in acetaminophen (APAP)-induced liver injury. mRNA expression of HMGB1 was enhanced in the liver of mice injected with APAP. Although HMGB1 protein was detected in hepatocyte nuclei of normal liver, it was observed in cytoplasm of hepatocytes after APAP challenge. The detection of HMGB1 in the liver could be considered as valuable diagnostic tools for the postmortem diagnosis of APAP-induced liver injury.
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