2012 Fiscal Year Final Research Report

The establishment of animal model for sarcopenia and clarification of the mechanism of sarcopenia: An investigation using an animal model for chronic obstructive pulmonary diseases

Research Project

Project/Area Number	23659379
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	General internal medicine (including Psychosomatic medicine)
Research Institution	Osaka University
Principal Investigator	RAKUGI Hiromi 大阪大学, 大学院・医学系研究科, 教授 (20252679)
Co-Investigator(Kenkyū-buntansha)	OHISHI Mirsuru 大阪大学, 大学院・医学系研究科, 講師 (50335345) SUGIMOTO Ken 大阪大学, 大学院・医学系研究科, 助教 (20437403) TACHIBANA Isao 大阪大学, 大学院・医学系研究科, 講師 (60324761)
Project Period (FY)	2011 – 2012
Keywords	老年医学
Research Abstract	We performed comparative analyses for phenotypes and molecular mechanisms between aged CD9/CD81 double knockout mice (DKO), an animal model for chronic obstructive pulmonary diseases and C57BL/6J mice (B6). Soleus muscle (SOL) mass was lower in DKO than in B6, however there was no difference in extensor digitorum longus muscle (EDL) mass between DKO and B6. The comprehensive genetic analysis using both muscle revealed the elevation of gene expressions related to apoptosis and inflammation in SOL and the change of gene expressions related to muscle protein synthesis in EDL of DKO. These findings suggest that DKO shows different gene-expression patterns among muscle fiber types.

(3 results)