2013 Fiscal Year Final Research Report
Elucidation of cell supply system focusing on stem cells
| Project/Area Number |
23659384
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 幹細胞 / 老年医学 / パーキンソン病 / 6-OHDA / 骨髄間葉系幹細胞 / ドーパミン神経 / ミクログリア |
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| Research Abstract |
We evaluated the multi-differentiation potential of mesenchymal stem cells from human peripheral blood (hPB-MSCs) to validate a hypothesis that the deteriorated supply system of innate stem cells induces neurodegenerative disease. Though the hypothesis was not completely endorsed, we continue to identify the optimal protocol of hPB-MSCs production. The therapeutic potential of MSCs from human bone marrow (hBM-MSCs) was evaluated in 6-OHDA induced Parkinson's disease(PD) model rats. Intravenous administration of hBM-MSCs inhibited drug-stimulated rotational behavior. Rats injected with hBM-MSCs displayed significant preservation of dopaminergic fibers in the striatum and dopaminergic neurons in the substantia nigra compared to those of control rats. The glial activity in the striatum was markedly inhibited by intravenous administration of hBM-MSCs. These findings raise the possibility that hBM-MSCs could be a novel therapeutic option to prevent PD development.
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