2012 Fiscal Year Final Research Report

Basic research for chronotherapy focused on liver regeneration andliver steatosis by circadian clock

Research Project

Project/Area Number	23659398
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Gastroenterology
Research Institution	Yamaguchi University
Principal Investigator	TERAI Shuji 山口大学, 大学院・医学系研究科, 准教授 (00332809)
Co-Investigator(Kenkyū-buntansha)	YAMAMOTO Naoki 山口大学, 大学教育機構, 講師 (90448283) TAKAMI Taro 山口大学, 大学院・医学系研究科, 講師 (60511251) FUJISAWA Koichi 山口大学, 大学院・医学系研究科, 助教 (00448284) SAKAIDA Isao 山口大学, 大学院・医学系研究科, 教授 (80263763)
Project Period (FY)	2011 – 2012
Keywords	NASH / 肝障害 / サーカディアンリズム
Research Abstract	Medaka with HFD showed high NASH activity score (NAS), suggesting that circadian rhythm change is related to NASH progression. The light system is closely related with chronic inflammation by light stimulation. Collaboration with Oklahoma university, we found that NASH medaka developed diabetic nephropathy. These data showedmedaka fish model is useful to analyze the mechanism of NASH and nephropathyand to develop a new chronotherapy.