2013 Fiscal Year Final Research Report
Role and function of taxilin in the complex formation of molecules related to intracellular signal transduction in a regenerating liver
| Project/Area Number |
23659403
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | タキシリン / 細胞内小胞輸送 / トランスフェリン / ソーティングネキシン / 微小管 / 再生肝 |
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| Research Abstract |
In this project, we attempted to reveal the mechanism by which -taxilin, a molecule related to vesicle transport, regulates intracellular delivery of molecules related to intracellular signal transduction. We obtained the following results: 1) -Taxilin was overexpressed in the regenerating liver after partial hepatectomy. 2) -Taxilin was localized on some intracellular organelles connected to the microtubule in Hela cells. 3) -Taxilin interacted with sorting nexin 4 and was implicated in the recycling of transferrin receptor. On the basis of these results, the possibility was raised that -taxilin might be involved in the complex formation of molecules related to intracellular signal transduction that are connected with transferrin receptor through regulating intracellular vesicle transport.
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Research Products
(12 results)
