2011 Fiscal Year Final Research Report
Elucidation of molecular mechanisms of lymphedema
| Project/Area Number |
23659412
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MANABE Ichiro 東京大学, 医学部・附属病院, 特任准教授 (70359628)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJIU Katsuhito 東京大学, 医学部・附属病院, 特任助教 (30422306)
EGUCHI Kosei 東京大学, 医学部・附属病院, 特任助教 (20529094)
MATSUMOTO Sahohime 東京大学, 医学部・附属病院, 特任助教 (80570184)
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| Project Period (FY) |
2011
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| Keywords | リンパ浮腫 / 慢性炎症 / リンパ管 |
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| Research Abstract |
In this project we addressed the mechanisms underlying the development of lymphedema. We found that an excessive generation(lymphangiogenesis) of immature lymphatic vessels pivotally contributes to the development of lymphedema in a mouse lymphedema model. Moreover, we found that inflammatory processes promote lymphangiogenesis. Furthermore, we identified chemical compounds that suppress lymphedema by inhibiting the inflammatory processes.
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Research Products
(11 results)
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[Journal Article] Saturated fatty acid and TLR signaling linkβcell dysfunction and islet inflammation2012
Author(s)
Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, Ogata F, Yagi N, Ohto U, Kimoto M, Miyake K, Tobe K, Arai H, Kadowaki T, Nagai R
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Journal Title
Cell Metab
Volume: 15
Pages: 518-533
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[Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling2012
Author(s)
Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich B, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R
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Journal Title
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