2012 Fiscal Year Final Research Report
Generation of a novel research area "sex difference in cardiovascular system based on XY chromosomes"
| Project/Area Number |
23659413
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 分子心臓病態学 |
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| Research Abstract |
There is gender difference in susceptibility to certain diseases and responses to drugs. This is partly attributed to the different gonad determined by SRY gene on the Y-chromosome, and resultant different sex hormones between male and female. However, the difference in the XY chromosome also contributes to the gender difference. The Y-chromosome containing about 80 genes is present only in male. In contrast, in female (YY) 10% of genes (about 100 genes) on the X-chromosome do not execute inactivation and thereby female has copy number for these 100 genes twice as many as male. However, the gender difference caused by the XY chromosome is poorly understood mainly because of technical deficit. In this project, we established XX♀、XX♂、XY♀、XY♂ mice by cross-hybridizing XY- SRY mice with wildtype XX female mice, and we collected the baseline data for cardiovascular functions.
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