2013 Fiscal Year Final Research Report
What is the physiological role of cardiac stem cells ?
| Project/Area Number |
23659417
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | The University of Tokyo (2013)
Osaka University (2011-2012) |
|---|
Principal Investigator |
NAITO Atsuhiko 東京大学, 医学部附属病院, 助教 (10588891)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 分子心臓病態学 / 心臓幹細胞 / c-kit |
|---|
| Research Abstract |
Accumulating evidence suggests the presence of so called 'cardiac stem cells'. However, physiological role of cardiac stem cells are not known yet. In this study, we tried to establish a mouse model that can induce Cre/LoxP recombination only in cardiac stem cells which express both c-kit and alpha MHC (aMHC). We have successfully established a transgenic mice which express Cre gene with nuclear localization sequence under the control of inducible aMHC promoter. By crossing with another transgenic mice which express tTA (tetracycline transactivator) or rtTA (reverse tTA), we can induce Cre/LoxP recombination exclusively in a specific type of cardiomyocytes, such as pacemaker cells, ventricular cells, and cardiac stem cells.
|
-
-
-
[Journal Article] Notch activation mediates angiotensin II-induced vascular remodeling by promoting the proliferation and migration of vascular smooth muscle cells2013
Author(s)
Ozasa Y, Akazawa H, Qin Y, Tateno K, Ito K, Kudo-Sakamoto Y, Yano M, Yabumoto C, Naito AT, Oka T, Lee JK, Minamino T, Nagai T, Kobayashi Y, Komuro I
-
Journal Title
Hypertens Res
Volume: 36(10)
Pages: 859-65
DOI
Peer Reviewed
-
-
-
[Journal Article] Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes2012
Author(s)
Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I
-
Journal Title
Cell
Volume: 149(6)
Pages: 1298-313
DOI
Peer Reviewed
-
[Journal Article] I. Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice2012
Author(s)
Yasuda N, Akazawa H, Ito K, Shimizu I, Kudo-Sakamoto Y, Yabumoto C, Yano M, Yamamoto R, Ozasa Y, Minamino T, Naito AT, Oka T, Shiojima I, Tamura K, Umemura S, Paradis P, Nemer M, Komuro
-
Journal Title
Hypertension
Volume: 59(3) (Epub)
Pages: 627-33
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
