Development of a novel treatment for coronary artery diseases by replacement of the epicardial adipose tissue

2011 Fiscal Year Final Research Report

• Project/Area Number: 23659420
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: The University of Tokushima
• Principal Investigator: SATA Masataka 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (80345214)
• Co-Investigator(Kenkyū-buntansha): SOEKI Takeshi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (60393211) ; TAKETANI Yoshio 徳島大学, 病院, 助教 (50563615) ; YAMAGUCHI Koji 徳島大学, 病院, 助教 (90531377)
• Project Period (FY): 2011
• Keywords: 動脈硬化 / 脂肪 / 移植 / 炎症 / 外膜 / 血管新生

Research Abstract

We demonstrated chronic inflammation in epicardial adipose tissues obtained from patients with coronary artery disease. Replacement of pericardial adipose tissues effectively reduced neointima formation after endovascular injury. Based upon these results, we are developing new cardiac bypass surgery by transplanting subcutaneous adipose tissues.

Research Products

• [Journal Article] Validation of longitudinal peak systolic strain by speckle tracking echocardiography with visual assessment and myocardial perfusion SPECT in patients with regional asynergy (2011)
  • Author(s): Kusunose, K., Yamada, H., Nishio, S., Mizuguchi, Y., Choraku, M., Maeda, Y., Hosokawa, S., Yamazaki, N., Tomita, N., Niki, T., Yamaguchi, K., Koshiba, K., Soeki, T., Wakatsuki, T., Akaike, M., Sata, M.
  • Journal Title: Circ J. Volume: 75 Pages: 141-147
  • DOI: doi:10.1253/circj.CJ-10-0551
  • Peer Reviewed
• [Journal Article] High plasma aldosterone concentration is a novel risk factor of cognitive impairment in patients with hypertension (2011)
  • Author(s): Yagi, S., Akaike, M., Aihara, KI., Iwase, T., Yoshida, S., Sumitomo-Ueda, Y., Ikeda, Y., Ishikawa, K., Matsumoto, T., Sata, M.
  • Journal Title: Hypertens Res Volume: 34 Pages: 74-78
  • DOI: doi:10.1038/hr.2010.179
  • Peer Reviewed
• [Journal Article] Hic-5 deficiency enhances mechanosensitive apoptosis and modulates vascular remodeling (2011)
  • Author(s): Kim-Kaneyama, JR., Takeda, N., Sasaki, A., Miyazaki, A., Sata, M., Hirabayashi, T., Shibanuma, M., Yamada, G., Nose, K.
  • Journal Title: J Mol Cell Cardiol Volume: 50 Pages: 77-86
  • DOI: doi:10.1016/j.yjmcc.2010.09.024
  • Peer Reviewed
• [Journal Article] Plasma heparin cofactor II activity is inversely associated with left atrial volume and diastolic dysfunction in humans with cardiovascular risk factors (2011)
  • Author(s): Ise, T., Aihara, K., Sumitomo-Ueda, Y., Yoshida, S., Ikeda, Y., Yagi, S., Iwase, T., Yamada, H., Akaike, M., Sata, M., Matsumoto, T.
  • Journal Title: Hypertens Res Volume: 34 Pages: 225-231
  • DOI: doi:10.1038/hr.2010.211
  • Peer Reviewed
• [Journal Article] Augmented angiogenesis in adventitia promotes growth of atherosclerotic plaque in apolipoprotein E-deficient mice (2011)
  • Author(s): Tanaka, K., Nagata, D., Hirata, Y., Tabata, Y., Nagai, R., Sata, M.
  • Journal Title: Atherosclerosis Volume: 215 Pages: 366-373
  • DOI: doi:10.1016/j.atherosclerosis.2011.01.016
  • Peer Reviewed
• [Journal Article] Bosentan improves systemic sclerosis-related peripheral circulation insufficiency (2011)
  • Author(s): Yagi, S., Akaike, M., Aihara, KI., Iwase, T., Sumitomo-Ueda, Y., Yoshida, S., Matsumoto, T., Sata, M.
  • Journal Title: Int J Cardiol Volume: 147 Pages: 472-475
  • DOI: doi:10.1016/j.ijcard.2011.01.025
  • Peer Reviewed
• [Journal Article] Acute hemodynamic effects of adaptive servo ventilation in patients with pulmonary hypertension (2011)
  • Author(s): Yagi, S., Akaike, M., Iwase, T., Kusunose, K., Niki, T., Yamaguchi, K., Koshiba, K., Taketani, Y., Tomita, N., Yamada, H., Soeki, T., Wakatsuki, T., Sata, M.
  • Journal Title: Int J Cardiol Volume: 148 Pages: 125-127
  • DOI: doi:10.1016/j.ijcard.2011.01.074
  • Peer Reviewed
• [Journal Article] Activation of peroxisome proliferator-activated receptorα in megakaryocytes reduces platelet-derived growth factor-BB in platelets (2011)
  • Author(s): Hashizume, S., Akaike, M., Azuma, H., Ishikawa, K., Yoshida, S., Sumitomo-Ueda, Y., Yagi, S., Ikeda, Y., Iwase, T., Aihara, K., Abe, M., Sata, M., Matsumoto, T.
  • Journal Title: J Atheroscler Thromb Volume: 18 Pages: 138-147
  • DOI: doi:10.5551/jat.5868
  • Peer Reviewed
• [Journal Article] Synergistic protection against vascular inflammation with a calcium channel blocker and a statin (2011)
  • Author(s): Hirata, Y., Sata, M.
  • Journal Title: Hypertens Res Volume: 34 Pages: 441-442
  • DOI: doi:10.1038/hr.2010.275
  • Peer Reviewed
• [Journal Article] Serial imaging changes during treatment of Takayasu arteritis with pulmonary artery stenosis (2011)
  • Author(s): Kusunose, K., Yamada, H., Tomita, N., Nishio, S., Niki, T., Yamaguchi, K., Koshiba, K., Yagi, S., Taketani, Y., Iwase, T., Soeki, T., Wakatsuki, T., Akaike, M., Sata, M.
  • Journal Title: Int J Cardiol Volume: 148 Pages: e47-e50
  • DOI: doi:10.1016/j.ijcard.2009.02.036
  • Peer Reviewed
• [Journal Article] Removal of pinched-off central venous catheter (2011)
  • Author(s): Kusunose, K., Wakatsuki, T., Sata, M.
  • Journal Title: Heart Asia Volume: 3 Pages: 32
  • DOI: doi:10.1136/ha.2009.001321
  • Peer Reviewed
• [Journal Article] Enhanced inflammation in epicardial fat in patients with coronary artery disease (2011)
  • Author(s): Hirata, Y., Kurobe, H., Akaike, M., Chikugo, F., Hori, T., Bando, Y., Nishio, C., Higashida, M., Nakaya, Y., Kitagawa, T., Sata, M.
  • Journal Title: Int Heart J. Volume: 52 Pages: 139-142
  • DOI: doi:10.1536/ihj.52.139
  • Peer Reviewed
• [Journal Article] Chronic inflammation and atherosclerosis : A critical role for renin angiotensin system that is activated by life-style related diseases (2011)
  • Author(s): Sata, M., Fukuda, D.
  • Journal Title: Inflamm Regen Volume: 31 Pages: 245-255
  • DOI: doi:10.2492/inflammregen.31.245
  • Peer Reviewed
• [Journal Article] Effect of low-dose(1 mg/ day) pitavastatin on left ventricular diastolic function and albuminuria in patients with hyperlipidemia (2011)
  • Author(s): Yagi, S., Akaike, M., Aihara, KI., Iwase, T., Ishikawa, K., Yoshida, S., Sumitomo-Ueda, Y., Kusunose, K., Niki, T., Yamaguchi, K., Koshiba, K., Taketani, Y., Tomita, N., Yamada, H., Soeki, T., Wakatsuki, T., Matsumoto, T., Sata, M.
  • Journal Title: Am J Cardiol Volume: 107 Pages: 1644-1649
  • DOI: doi:10.1016/j.amjcard.2011.01.054
  • Peer Reviewed
• [Journal Article] Ventricular tachycardia in cardiac sarcoidosis controlled by radiofrequency catheter ablation (2011)
  • Author(s): Bando, M., Soeki, T., Niki, T., Kusunose, K., Tomita, N., Yamaguchi, K., Koshiba, K., Taketani, Y., Iwase, T., Yamada, H., Wakatsuki, T., Akaike, M., Sata, M.
  • Journal Title: Intern Med Volume: 50 Pages: 1201-1206
  • DOI: doi:10.2169/internalmedicine.50.4580
  • Peer Reviewed
• [Journal Article] Pre-clinical data on the role of mineralocorticoid receptor antagonists in reversing vascular inflammation (2011)
  • Author(s): Yagi, S., Sata, M.
  • Journal Title: Eur Heart J Suppl Volume: 13 Pages: B15-B20
  • DOI: doi:10.1093/eurheartj/sur012
  • Peer Reviewed
• [Journal Article] Preparation of double-raschel knitted silk vascular grafts and evaluation of short-term function in a rat abdominal aorta (2011)
  • Author(s): Yagi, T., Sato, M., Nakazawa, Y., Tanaka, K., Sata, M., Itoh, K., Takagi, Y., Asakura, T.
  • Journal Title: J Artif Organs Volume: 14 Pages: 89-99
  • DOI: doi:10.1007/s10047-011-0554-z
  • Peer Reviewed
• [Journal Article] Observation of short-term atorvastatin-induced changes in coronary arterial plaque properties using integrated backscatter intravascular ultrasound in a patient (2011)
  • Author(s): Yamaguchi, K., Wakatsuki, T., Niki, T., Taketani, Y., Oezuka, H., Kusunose, K., Iwase, T., Yamada, H., Soeki, T., Sata, M.
  • Journal Title: JC Cases Volume: 3 Pages: e111-e114
  • DOI: doi:10.1016/j.jccase.2011.03.007
  • Peer Reviewed
• [Journal Article] Relationships among hyperuricemia, metabolic syndrome, and endothelial function (2011)
  • Author(s): Tomiyama, H., Higashi, Y., Takase, B., Node, K., Sata, M., Inoue, T., Ishibashi, Y., Ueda, S., Shimada, K., Yamashina, A.
  • Journal Title: Am J Hypertens. Volume: 24 Pages: 770-774
  • DOI: doi:10.1038/ajh.2011.55.
  • Peer Reviewed
• [Journal Article] macrophage polarization in epicardial adipose tissue (2011)
  • Author(s): Hirata, Y., Tabata, M., Kurobe, H., Motoki, T., Akaike, M., Nishio, C., Higashida, M., Mikasa, H., Nakaya, Y., Takanashi, S., Igarashi, T., Kitagawa, T., Sata, M.
  • Journal Title: J Am Coll Cardiol. Volume: 58 Pages: 248-255
  • DOI: doi:10.1016/j.jacc.2011.01.048
  • Peer Reviewed
• [Journal Article] Comparison of chronic-stage histopathological findings among 3 coronary stents implanted in the same patient (2011)
  • Author(s): Niki, T., Wakatsuki, T., Yamaguchi, K., Kusunose, K., Koshiba, K., Yagi, S., Taketani, Y., Iwase, T., Tomita, N., Yamada, H., Soeki, T., Akaike, M., Sata, M.
  • Journal Title: Int J Cardiol Volume: 150 Pages: e25-e27
  • DOI: doi:10.1016/j.ijcard.2009.08.032
  • Peer Reviewed
• [Journal Article] A patient who developed toe necrosis due to poor blood circulation after an interdigital tick bite (2011)
  • Author(s): Yamazaki, H., Yamaguchi, K., Iwase, T., Niki, T., Kusunose, K., Tomita, N., Taketani, Y., Yamada, H., Soeki, T., Wakatsuki, T., Fukunaga, Y., Nakanishi, H., Maruyama, H., Matsuoka, H., Sata, M.
  • Journal Title: JC Cases Volume: 4 Pages: e106-e109
  • DOI: doi:10.1016/j.jccase.2011.06.005
  • Peer Reviewed
• [Journal Article] A synthetic prostacycline agonist, ONO-1301, ameliorates ventricular remodeling after acute myocardial infarction via up-regulation of HGF in rat (2011)
  • Author(s): Hirata, Y., Soeki, T., Yamada, H., Shiota, A., Shimabukuro, M., Sakai, Y., Nakayama, M., Matsumoto, K., Igarashi, T., Sata, M.
  • Journal Title: Biomed Aging Pathol Volume: 1 Pages: 90-96
  • DOI: doi:10.1016/j.biopha.2009.09.003
  • Peer Reviewed
• [Journal Article] Elevated concentrations of pentraxin 3 are associated with coronary plaque vulnerability (2011)
  • Author(s): Soeki, T., Niki, T., Kusunose, K., Bando, S., Hirata, Y., Tomita, N., Yamaguchi, K., Koshiba, K., Yagi, S., Taketani, Y., Iwase, T., Yamada, H., Wakatsuki, T., Akaike, M., Sata, M.
  • Journal Title: J Cardiol Volume: 58 Pages: 151-157
  • DOI: doi:10.1016/j.jjcc.2011.04.005
  • Peer Reviewed
• [Journal Article] High phosphate diet reduces atherosclerosis formation in apolipoprotein E-deficient mice (2011)
  • Author(s): Shiota, A., Taketani, Y., Maekawa, Y., Yasutomo, K., Sata, M., Sakai, T., Mizuno, R., Isshiki, M., Yamamoto, H., Takeda, E.
  • Journal Title: J Clin Biochem Nutr Volume: 49 Pages: 109-114
  • DOI: doi:10.3164/jcbn.10-150
  • Peer Reviewed
• [Journal Article] Reproducibility and diagnostic accuracy of three-layer speckle tracking echocardiography in a swine chronic ischemia model (2011)
  • Author(s): Kimura, K., Takenaka, K., Ebihara, A., Uno, K., Iwata, H., Sata, M., Kohro, T., Morita, H., Yatomi, Y., Nagai, R.
  • Journal Title: Echocardiography Volume: 28 Pages: 1148-1155
  • DOI: doi:10.1111/j.1540-8175.2011.01517.x.
  • Peer Reviewed
• [Journal Article] Local persistent hypercoagulability after sirolimus-eluting stent implantation in patients with stable angina (2011)
  • Author(s): Yamaguchi, K., Wakatsuki, T., Niki, T., Kusunose, K., Koshiba, K., Yagi, S., Taketani, Y., Iwase, T., Tomita, N., Yamada, H., Soeki, T., Akaike, M., Sata, M.
  • Journal Title: Int J Cardiol Volume: 153 Pages: 272-276
  • DOI: doi:10.1016/j.ijcard.2010.08.014
  • Peer Reviewed
• [Journal Article] Ezetimibe monotherapy ameliorates vascular function in patients with hypercholesterolemia through decreasing oxidative stress (2011)
  • Author(s): Kurobe, H., Aihara, KI., Higashida, M., Hirata, Y., Nishiya, M., Matsuoka, Y., Kanbara, T., Nakayama, T., Kinoshita, H., Sugano, M., Fujimoto, E., Kurobe, A., Sugasawa, N., Kitaichi, T., Akaike, M., Sata, M., Matsumoto, T., Kitagawa, T.
  • Journal Title: J Atheroscler Thromb Volume: 18 Pages: 1080-1089
  • DOI: doi:10.5551/jat.9548
  • Peer Reviewed
• [Journal Article] Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice (2011)
  • Author(s): Higashikuni, Y., Takaoka, M., Iwata, H., Tanaka, K., Hirata, Y., Nagai, Y., Sata, M.
  • Journal Title: Hypertens Res Volume: 12 ; 35 Pages: 62-69
  • DOI: doi:10.1038/hr.2011.136.
  • Peer Reviewed
• [Journal Article] A synthetic prostacyclin agonist thromboxane synthase inhibitory activity, ONO-1301, protects myocardium from ischemia/ reperfusion injury (2011)
  • Author(s): Hirata, Y., Shimabukuro, M., Uematsu, E., Soeki, T., Yamada, H., Sakai, Y., Nakamura, M., Matsumoto, K., Igarashi, T., Sata, M.
  • Journal Title: Eur J Pharmacol Volume: 674 Pages: 352-358
  • DOI: doi:10.1016/j.ejphar.2011.10.038
  • Peer Reviewed
• [Journal Article] The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response (2011)
  • Author(s): Higashikuni, Y., Sainz, J., Nakamura, K., Takaoka, M., Enomoto, S., Hiroshi, I., Kimie, T., Sahara, M., Hirata, Y., Nagai, R., Sata, M.
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 32 Pages: 654-661
  • DOI: doi:10.1161/ATVBAHA.111.240341
  • Peer Reviewed
• [Journal Article] Intensive Glucose Lowering in Cardiovascular Risk Management (2011)
  • Author(s): Shimabukuro, M., Masuzaki, H., Sata, M.
  • Journal Title: Circ J. Volume: 76 Pages: 593-595
  • DOI: doi:10.1253/circj.CJ-12-0062
  • Peer Reviewed
• [Journal Article] The Radioprotective 105/ MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation (2011)
  • Author(s): Watanabe, Y., Nakamura, T., Ishikawa, S., Fujisaka, S., Usui, I., Tsuneyama, K., Ichihara, Y., Wada, T., Hirata, Y., Suganami, T., Izaki, H., Akira, S., Miyake, K., Kanayama, H., Shimabukuro, M., Sata, M., Sasaoka, T., Ogawa, Y., Tobe, K., Takatsu, K., and Nagai, Y.
  • Journal Title: Diabetes Volume: 61 Pages: 1199-1209
  • DOI: doi:10.2337/db11-1182
  • Peer Reviewed
• [Presentation] Detection of Cardiac Involvement in Patients with Sarcoidosis Using Cardiac Magnetic Resonance (2011)
  • Author(s): Iwase, T., Takao, S., Akaike, M., Ise, T., Niki, T., Kusunose, K., Sumitomo-Ueda, Y., Tomita, N., Yamaguchi, K., Taketani, Y., Yamada, H., Soeki, T., Aihara, K., Wakatsuki, T., Harada, M., Sata, M.
  • Organizer: AHA Scientific Sessions 2011
  • Place of Presentation: Orange Country Conversion Center(米国オーランド)
  • Year and Date: 20111112-16
• [Presentation] Effects of Telmisartan on Inflammatory Cytokines and Coronary Plaque Component Assessed by Integrated Backscatter Intravascular Ultrasound in Hypertensive Patients (2011)
  • Author(s): Yamaguchi, K., Wakatsuki, T., Soeki, T., Niki, T., Taketani, Y., Oezuka, H., Bando, S., Tomita, N., Kusunose, K., Iwase, T., Yamada, H., Sata, M.
  • Organizer: AHA Scientific Sessions 2011
  • Place of Presentation: Orange Country Conversion Center(米国オーランド)
  • Year and Date: 20111112-16
• [Presentation] Ultrasonic Tissue Characterization of Carotid Artery Plaque using High-resolution Integrated Backscatter Imaging ; Validation Study with Histological Correlation. (2011)
  • Author(s): Bando, M., Yamada, H., Nishio, S., Uematsu, E., Hayashi, S., Hotchi, J., Kusunose, K., Tomita, N., Tamai, R., Hirata, Y., Hirota, D., Nakagawa, M., Niki, T., Yamaguchi, K., Taketani, Y., Iwase, T., Soeki, T., Wakatsuki, T., Shimabukuro, M., Sata, M.
  • Organizer: AHA Scientific Sessions 2011
  • Place of Presentation: Orange Country Conversion Center(米国オーランド)
  • Year and Date: 20111112-16
• [Presentation] Pentraxin 3 is a Local Inflammatory Maker in Atrial Fibrillation (2011)
  • Author(s): Soeki, T., Bando, S., Niki, T., Yamazaki, H., Takashima, A., Ogasawara, K., Bando, M., Ise, T., Takeuchi, H., Tomita, N., Ueda, Y., Kusunose, K., Yamaguchi, K., Taketani, Y., Iwase, T., Yamada, H., Wakatsuki, T., Sata, M.
  • Organizer: AHA Scientific Sessions 2011
  • Place of Presentation: Orange Country Conversion Center(米国オーランド)
  • Year and Date: 20111112-16
• [Presentation] HMGB1 Signal via TLR9 Plays Critical Role in Vascular Remodeling (2011)
  • Author(s): Higashida, M., Hirata, Y., Kurobe, H., Nakaya, Y., Kitagawa, T., Sata, M.
  • Organizer: AHA Scientific Sessions 2011
  • Place of Presentation: Orange Country Conversion Center(米国オーランド)
  • Year and Date: 20111112-16
• [Presentation] Single-Beat Assessment of Left Ventricular Systolic and Diastolic Function during Atrial Fibrillation using Myocardial Strain and Strain Rate (2011)
  • Author(s): Kusunose, K., Yamada, H., Nishio, S., Tomita, N., Hayashi, S., Hotchi, J., Tamai, R., Hirota, D., Hirata, Y., Bando, M., Ogasawara, K., Takashima, A., Yamazaki, H., Bando, S., Ise, T., Niki, T., Yamaguchi, K., Taketani, Y., Iwase, T., Soeki, T., Wakatsuki, T., Sata, M.
  • Organizer: AHA Scientific Sessions 2011
  • Place of Presentation: Orange Country Conversion Center(米国オーランド)
  • Year and Date: 20111112-16
• [Presentation] 心臓周囲脂肪におけるインフラマゾームの病態的意義 (2011)
  • Author(s): 佐藤寛美、平田陽一郎、島袋充生、塩田あすか、田端実、黒部裕嗣、東田真由子、井崎博文、金山博臣、高梨秀一郎、中屋豊、北川哲也、佐田政隆
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫県淡路市)
  • Year and Date: 20110923-24
• [Presentation] テルミサルタンは、beyond AT1R作用により動脈硬化抑制作用を示す (2011)
  • Author(s): 塩田あすか、福田大受、佐藤寛美、東田真由子、榎本操一郎、平田陽一郎、黒部裕嗣、佐田政隆
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫県淡路市)
  • Year and Date: 20110923-24
• [Presentation] エイコサペンタエン酸は高脂血症において脂肪酸構成を変化させ、血管内皮機能を改善する (2011)
  • Author(s): 山川研、比嘉南夫、旭朝弘、比嘉盛丈、大城義人、植田真一郎、益崎裕章、佐田政隆、島袋充生
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫県淡路市)
  • Year and Date: 20110923-24
• [Presentation] Heparin Cofactor II Promotes Angiogenesis via an AMPK-eNOS Signaling Pathway (2011)
  • Author(s): Ikeda, Y., Aihara, K., Yoshida, S., Kihira, Y., Ishizawa, K., Izawa-Ishizawa, Y., Tomita, S., Sata, M., Akaike, M.
  • Organizer: American Heart Association HBPR 2011
  • Place of Presentation: Walt Disney World Dolphin Resort(米国オーランド)
  • Year and Date: 20110920-24
• [Presentation] HMGB1/ TLR9 pathway plays a critical role in chronic inflammation and vascular remodeling after endovascular injury (2011)
  • Author(s): Higashida, M., Hirata, Y., Kurobe, H., Nakaya, Y., Kitagawa, T., Sata, M.
  • Organizer: ESC Congress 2011
  • Place of Presentation: Paris Nord Villepinte exhibition center(フランス、パリ)
  • Year and Date: 20110827-31
• [Presentation] Long-term local inflammatory and coagulative responses after coronary artery stenting with drug-eluting stent (2011)
  • Author(s): Wakatsuki, T., Niki, T., Yamaguchi, K., Taketani, Y., Iwase, T., Kusunose, K., Bando, S., Yamada, H., Soeki, T., Sata, M.
  • Organizer: ESC Congress 2011
  • Place of Presentation: Paris Nord Villepinte exhibition center(フランス、パリ)
  • Year and Date: 20110827-31
• [Presentation] Elevated concentration of pentraxin 3 is associated with local inflammation in atrial fibrillation (2011)
  • Author(s): Soeki, T., Bando, S., Niki, T., Kusunose, K., Yamaguchi, K., Taketani, Y., Iwase, T., Yamada, H., Wakatsuki, T., Sata, M.
  • Organizer: ESC Congress 2011
  • Place of Presentation: Paris Nord Villepinte exhibition center(フランス、パリ)
  • Year and Date: 20110827-31
• [Presentation] Deterioration of right ventricular myocardial systolic function in monocrotaline-induced pulmonary arterial hypertension canine model : echocardiographic evaluation by 2D speckle tracking (2011)
  • Author(s): Nishio, S., Yamada, H., Tamai, R., Endo, K., Hayashi, S., Kusunose, K., Soeki, T., Wakatsuki, T., Sakai, Y., Sata, M.
  • Organizer: ESC Congress 2011
  • Place of Presentation: Paris Nord Villepinte exhibition center(フランス、パリ)
  • Year and Date: 20110827-31
• [Presentation] GLP-1 receptor agonist attenuates vascular remodeling after endovascular injury (2011)
  • Author(s): Hirata, Y., Kurobe, H., Higashida, M., Nakaya, Y., Kitagawa, T., Sata, M.
  • Organizer: ESC Congress 2011
  • Place of Presentation: Paris Nord Villepinte exhibition center(フランス、パリ)
  • Year and Date: 20110827-31
• [Presentation] Impact of abdominal obesity and insulin resistance on cardiovascular events in Japanese obesity-endemic area : Okinawa Tomishiro Cohort Study (2011)
  • Author(s): Shimabukuro, M., Higa, M., Yamakawa, K., Masuzaki, H., Sata, M.
  • Organizer: ESC Congress 2011
  • Place of Presentation: Paris Nord Villepinte exhibition center(フランス、パリ)
  • Year and Date: 20110821-31