2013 Fiscal Year Final Research Report
The role of hypoxia response system in the development of cardiovascular and metabolic diseases
| Project/Area Number |
23659421
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ICHIKI Toshihiro 九州大学, 大学院・医学研究院, 教授 (80311843)
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| Project Period (FY) |
2012 – 2013
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| Keywords | 分子血管病態学 / 低酸素応答系 / 生活習慣病 |
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| Research Abstract |
Inhibition of prolyl hydorxlyase (PHD), an oxygen sensor, suppressed anigotensin II receptor expression in vascular smooth muscle cells and angiotensin II-induced cardiac fibrosis. Mice with targeted deletion of PHD isoform 2 in adipocytes were resistant to high-fat diet-induced obesity and glucose intolerance. PHD inhibition may be a novel strategy for the treatment of cardiovascular diseases and metabolic syndrome.
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