• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Final Research Report

Identification of individuals with augmented functions of blood pressure-lowering peptides

Research Project

  • PDF
Project/Area Number 23659422
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionUniversity of Miyazaki

Principal Investigator

KATO Johji  宮崎大学, フロンティア科学実験総合センター, 教授 (20274780)

Project Period (FY) 2011 – 2013
Keywordsナトリウム利尿ペプチド / アドレノメデュリン / 機能増強個体 / 心血管疾患 / 慢性腎臓病 / 疾患マーカー
Research Abstract

The aims of the present study are to identify individuals protected from cardiovascular or renal diseases by augmented functions of the hypotensive peptides, ANP, BNP, and adrenomedullin (AM), through the regular health check-up program, and to clarify the mechanisms. First, we found healthy residents who had shown relatively higher plasma levels of ANP or BNP, but not developed hypertension, and currently we continue to follow-up those individual while increasing the number of samples. Second, examining the relationship between the plasma levels of hypotensive peptides and development of chronic kidney disease (CKD), we found that the higher the peptide levels, the more frequent the future development of CKD. This suggests a possibility for those hypotensive peptides as markers of CKD development.

  • Research Products

    (24 results)

All 2014 2013 2012 2011 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Gender difference in relationship between body mass index and development of chronic kidney disease2013

    • Author(s)
      Komura H, Nomura I, Kitamura K, Kuwasako K, Kato J
    • Journal Title

      BMC Res Notes

      Volume: 6 Pages: 463

    • DOI

      10.1186/1756-0500-6-463

    • Peer Reviewed
  • [Journal Article] Reduced fractional shortening of right ventricular outflow tract is associated with adverse outcomes in patients with left ventricular dysfunction2013

    • Author(s)
      Yamaguchi M, Tsuruda T, Watanabe Y, Onitsuka H, Furukawa K, Ideguchi T, Kawagoe J, Ishikawa T, Kato J, Takenaga M, Kitamura K
    • Journal Title

      Cardiovasc Ultrasound

      Volume: 11 Pages: 19

    • URL

      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681625/

    • Peer Reviewed
  • [Journal Article] Big angiotensin-25 : A novel glycosylated angiotensin-related peptide isolated from human urine2013

    • Author(s)
      Nagata S, Hatakeyama K, Asami M, Tokashiki M, Hibino H, Nishiuchi Y, Kuwasako K, Kato J, Asada Y, Kitamura K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 441 Pages: 757-762

    • DOI

      10.1016/j.bbrc.2013.10.124

    • Peer Reviewed
  • [Journal Article] Hemodynamic and hormonal changes to dual renin-angiotensin system inhibition in experimental hypertension2013

    • Author(s)
      Moniwa N, Varagic J, Ahmad S, VonCannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, Lopez ML, Ferrario CM
    • Journal Title

      Hypertension

      Volume: 61 Pages: 417-724

    • DOI

      10.1161/HYPERTENSIONAHA.112.201889

    • Peer Reviewed
  • [Journal Article] GEANE study group; HOMED-BP study group. Genome-wide response to antihypertensive medication using home blood pressure measurements : a pilot study nested within the HOMED-BP study2013

    • Author(s)
      Kamide K, Asayama K, Katsuya T, Ohkubo T, Hirose T, Inoue R, Metoki H, Kikuya M, Obara T, Hanada H, Thijs L, Kuznetsova T, Noguchi Y, Sugimoto K, Ohishi M, Morimoto S, Nakahashi T, Takiuchi S, Ishimitsu T, Tsuchihashi T, Soma M, Higaki J, Matsuura H, Shinagawa T, Sasaguri T, Miki T, Takeda K, Shimamoto K, Ueno M, Hosomi N, Kato J, Komai N, Kojima S, Sase K, Miyata T, Tomoike H, Kawano Y, Ogihara T, Rakugi H, Staessen JA, Imai Y
    • Journal Title

      Pharmacogenomics

      Volume: 14 Pages: 1709-1721

    • DOI

      10.2217/pgs.13.161

    • Peer Reviewed
  • [Journal Article] Obesity paradox in peripheral vascular disease2013

    • Author(s)
      Kato J
    • Journal Title

      Atherosclerosis

      Volume: 229 Pages: 509-510

    • DOI

      10.1016/j.atherosclerosis.2013.05.004

    • Peer Reviewed
  • [Journal Article] Functions Of Third Extracellular Loop And Helix 8 of Family B GPCRs complexed with RAMPs and Characteristics Of Their Receptor Trafficking2013

    • Author(s)
      Kuwasako K, Hay DL, Nagata S, Murakami M, Kitamura K, Kato J
    • Journal Title

      Curr Protein Pept Sci

      Volume: 14 Pages: 416-428

    • DOI

      10.2174/13892037113149990058

    • Peer Reviewed
  • [Journal Article] Effects of proangiotensin-12 infused continuously over 14days in conscious rats2012

    • Author(s)
      Komatsu Y, Kida N, Nozaki N, Kuwasako K, Nagata S, Kitamura K, Kato J
    • Journal Title

      Eur J Pharmacol

      Volume: 683 Pages: 186-189

    • DOI

      10.1016/j.ejphar.2012.02.037

    • Peer Reviewed
  • [Journal Article] The third extracellular loop of the human calcitonin receptor-like receptor is crucial for the activation of adrenomedullin signalling2012

    • Author(s)
      Kuwasako K, Hay DL, Nagata S, Hikosaka T, Kitamura K, Kato J
    • Journal Title

      Br J Pharmacol

      Volume: 166 Pages: 137-150

    • DOI

      10.1111/j.1476-5381.2011.01803.x

    • Peer Reviewed
  • [Journal Article] Characterization of the single transmembrane domain of human receptor activity-modifying protein 3 in adrenomedullin receptor internalization2012

    • Author(s)
      Kuwasako K, Kitamura K, Nagata S, Nozaki N, Kato J
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 420 Pages: 582-587

    • DOI

      10.1016/j.bbrc.2012.03.037

    • Peer Reviewed
  • [Journal Article] Plasma and tissue concentrations of proangiotensin-12 in rats treated with inhibitors of the renin-angiotensin system2012

    • Author(s)
      Nagata S, Kato J, Kuwasako K, Asami M, Kitamura K
    • Journal Title

      Hypertens Res

      Volume: 35 Pages: 234-238

    • DOI

      10.1038/hr.2011.165

    • Peer Reviewed
  • [Journal Article] ifferential blood pressure reductions by angiotensin receptor blocker plus calcium channel blocker or diuretic in elderly hypertension with or without obesity2012

    • Author(s)
      Kato J, Yokota N, Tamaki N, Kariya S, Kita T, Ayabe T, Eto T, Kitamura K
    • Journal Title

      J Am Soc Hypertens

      Volume: 6 Pages: 393-398

    • DOI

      10.1016/j.jash.2012.09.001

    • Peer Reviewed
  • [Journal Article] Isolation of the bioactive peptides CCHamide-1 and CCHamide-2 from Drosophila and their putative role in appetite regulation as ligands for G protein-coupled receptors2012

    • Author(s)
      Ida T, Takahashi T, Tominaga H, Sato T, Sano H, Kume K, Ozaki M, Hiraguchi T, Shiotani H, Terajima S, Nakamura Y, Mori K, Yoshida M, Kato J, Murakami N, Miyazato M, Kangawa K, Kojima M
    • Journal Title

      Front Endocrinol

      Volume: 3 Pages: 177

    • DOI

      10.3389/fendo.2012.00177

    • Peer Reviewed
  • [Journal Article] Shared and separate functions of the RAMP-based adrenomedullin receptors2011

    • Author(s)
      Kuwasako K, Kitamura K, Nagata S, Hikosaka T, Takei Y, Kato J
    • Journal Title

      Peptides

      Volume: 32 Pages: 1540-1550

    • DOI

      10.1016/j.peptides.2011.05.022

    • Peer Reviewed
  • [Journal Article] Identification of the endogenous cysteine-rich peptide trissin, a ligand for an orphan G protein-coupled receptor in Drosophila2011

    • Author(s)
      Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Yoshizawa-Kumagaye K, Nishio H, Kato J, Murakami N, Miyazato M, Kangawa K, Kojima M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 414 Pages: 44-48

    • DOI

      10.1016/j.bbrc.2011.09.018

    • Peer Reviewed
  • [Journal Article] Structure-function analysis of helix 8 of human calcitonin receptor-like receptor within the adrenomedullin 1 receptor2011

    • Author(s)
      Kuwasako K, Kitamura K, Nagata S, Hikosaka T, Kato J
    • Journal Title

      Peptides

      Volume: 32 Pages: 144-149

    • DOI

      10.1016/j.peptides.2010.10.005

    • Peer Reviewed
  • [Journal Article] Identification of the novel bioactive peptides dRYamide-1 and dRYamide-2, ligands for a neuropeptide Y-like receptor in Drosophila2011

    • Author(s)
      Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Ozaki M, Hiraguchi T, Maeda T, Shiotani H, Terajima S, Sano H, Mori K, Yoshida M, Miyazato M, Kato J, Murakami N, Kangawa K, Kojima M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 410 Pages: 872-877

    • DOI

      10.1016/j.bbrc.2011.06.081

    • Peer Reviewed
  • [Journal Article] Comparison of combination therapies, including the angiotensin receptor blocker olmesartan and either a calcium channel blocker or a thiazide diuretic, in elderly patients with hypertension2011

    • Author(s)
      Kato J, Yokota N, Tamaki N, Kariya S, Kita T, Ayabe T, Eto T, Kitamura K
    • Journal Title

      Hypertens Res

      Volume: 34 Pages: 331-335

    • DOI

      10.1038/hr.2010.233

    • Peer Reviewed
  • [Journal Article] Adrenomedullin in hypertension and obesity2011

    • Author(s)
      Kato J, Kuwasako K, Kitamura K
    • Journal Title

      Curr Hypertens Rev

      Volume: 7 Pages: 257-267

    • DOI

      10.2174/157340211799304770

    • Peer Reviewed
  • [Journal Article] Molecular basis of adrenomedullin 1 receptor function and its roles in the cardiovascular system2011

    • Author(s)
      Kuwasako K, Kitamura K, Nagata S, Kato J
    • Journal Title

      Curr Hypertens Rev

      Volume: 7 Pages: 207-216

    • DOI

      10.2174/157340211799304743

    • Peer Reviewed
  • [Book] Adrenomedullin Peptides. In : Kastin AJ, ed. Handbook of Biologically Active Peptides2013

    • Author(s)
      Kato J, Kitamura K
    • Total Pages
      1361-1368
    • Publisher
      Academic Press, San Diego
  • [Remarks]

    • URL

      http://www.med.miyazaki-u.ac.jp/peptides/katou/jp/

  • [Patent(Industrial Property Rights)] 急性腎障害に起因する多臓器不全の予防又は治療薬2014

    • Inventor(s)
      池田正浩、園田紘子,北村和雄,加藤丈司
    • Industrial Property Rights Holder
      国立大学法人宮崎大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      特願2014-036815
    • Filing Date
      2014-02-27
  • [Patent(Industrial Property Rights)] 長時間作用型アドレノメデュリン誘導体2014

    • Inventor(s)
      北村和雄,加藤丈司,久保恵是,桑迫健二,久保茂,熊谷久美子
    • Industrial Property Rights Holder
      国立大学法人宮崎大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      特願2014-058225
    • Filing Date
      2014-03-20

URL: 

Published: 2015-06-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi