2012 Fiscal Year Final Research Report
Molecular mechanism of alveolar formation
| Project/Area Number |
23659428
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Chiba University |
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Principal Investigator |
HATANO Masahiko 千葉大学, 大学院・医学研究院, 教授 (20208523)
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| Co-Investigator(Kenkyū-buntansha) |
ARIMA Masafumi 千葉大学, 大学院・医学研究院, 講師 (00202763)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 閉塞性肺疾患 |
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| Research Abstract |
We analyzed molecular mechanism of alveolization using DA-Raf KO mice. DA-RafKO mice have defects in alveolar septum formation and alveolization during neonatalperiods. Myofibroblast differentiation was severely blocked in P2～P5 of development inthe KO mice. DA-Raf mRNA is highly expressed in type II alveolar epithelial cells(AEII). Lineage trace experiment using SPC-CreER and LacZ floxed mice revealedthat AEII cells did not differentiate to myofibroblasts in neonatal periods. Thus, DARafregulates myofibroblast differentiation by suppressing Ras-ERK cascade in noncellautonomousmanner in neonatal period of lung development.
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[Journal Article] ADAR1 protein induces denosine-targeted DNA mutations in enescent Bcl6 gene-deficient cells.2013
Author(s)
Tsuruoka N., Arima M., Yoshida N., Okada S., Sakamoto A., Hatano M., Satake H., Arguni E., Wang J-Y., Yang J-H., Nishikura K., Sekiya S, Shozu M., and Tokuhisa T.
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Journal Title
J Biol Chem
Volume: 288
Pages: 826-836
DOI
Peer Reviewed
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[Journal Article] BAZF, a novel component of cullin3-based E3 ligase complex, mediates VEGFR and Notch cross-signaling in angiogenesis2012
Author(s)
Ohnuki H., Inoue H., Takemori N., Nakayama H., Sakaue T., Fukuda S., Miwa D., Nishiwaki E., Hatano M., Tokuhisa T., Endo Y., Nose M. and Higashiyama S.
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Journal Title
Blood
Volume: 119
Pages: 2688-2698
DOI
Peer Reviewed
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[Journal Article] Bcl6 in pulmonary epithelium coordinately controls the expression of the CC-type chemokine genes and attenuates allergic airway inflammation airway inflammation2011
Author(s)
Seto T., Yoshitake, M., Ogasawara, T., Ikari, J., Sakamoto, A., Hatano, M., Hirata, H., Fukuda, T., Kuriyama, T., Tatsumi, K., Tokuhisa, T., andArima, M.
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Journal Title
Clin Exp Allergy
Volume: 41
Pages: 1568-1578
DOI
Peer Reviewed
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