2012 Fiscal Year Final Research Report
Clarification of mechanism of renoprotective effect by renal oxygen metabolism and development of imaging method for renal function evaluation.
| Project/Area Number |
23659438
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
MORI Takefumi 東北大学, 大学院・医学系研究科, 准教授 (40375001)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Sadayoshi 東北大学, 大学院・医学系研究科, 教授 (40271613)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Nobuyuki 東北大学, 大学院・薬学研究科, 准教授 (40588456)
KANETA Tomohiro 東北大学, 病院, 講師 (50323019)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 腎臓病 / 低酸素 / prolyl hydroxylase / 虚血 / 酸化ストレス / ノックアウトマウ ス / ミトコンドリア |
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| Research Abstract |
Hypoxia induced mitochondrial oxidative stress in renal medullary thick ascending limb of loop of Henle. Treatment with Mito-TEMPO significantly attenuated the reduction of renal medullary blood flow induced by ischemia/reperfusion. We established methods to evaluate renal function with [^<15>O]H_2O-PET and [^<18>F]FRP-170-PET. We created conditional prolyl hydroxylase (PHD) knockout mice, and measured the response of renal medullary blood flow in those mice. These results indicated that hypoxia could exacerbate renal injury though increase of mitochondrial oxidative stress and following reduction of renal medullary blood flow.
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[Journal Article] Role of specific T-type calcium channel blocker R(-) efonidipine in the regulation of renal medullary circulation2012
Author(s)
Chunyan Hu, Takefumi Mori, Yi Lu, Qi Guo, Ying Sun, Yoshimi Yoneki, Yusuke Ohsaki, Takashi Nakamichi, Ikuko Oba,Emiko Sato, Susumu Ogawa, Dickinson BC, Chang CJ, Toshio Miyata, Hiroshi Sato, Sadayoshi Ito
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Journal Title
J Hypertens
Volume: 30(8)
Pages: 1620-1631
URL
Peer Reviewed
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[Presentation] The Effects of Extracorporeal Shock2012
Author(s)
Mai Yoshida, Takashi Nakamichi, Takefumi Mori, Kenta Ito, Hiroaki Shimokawa, Sadayoshi Ito
Organizer
Wave for Renal Ischemia ReperfusionInjury in Rats.Kidney Week
Place of Presentation
San Diego, CA, US
Year and Date
20121030-1105
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[Presentation] Angiotensin II increases mitochondrial reactive oxygen species through mitochondrial respiratory chain in renal medullary thick ascending limb2011
Author(s)
Yi Lu, Takefumi Mori, Chunyan Hu, Yusuke Ohsaki, Yoshimi Yoneki, Rieko Fujita, Susumu Ogawa, Bryan C.Dickinson, Christopher J.Chang, Allen W. Cowley, Jr, Sadayoshi Ito
Organizer
The 13th International Symposium onHypertension and Related Diseases
Place of Presentation
Beijing, China
Year and Date
20111104-06
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[Presentation] Expression of (pro)renin Receptor in the Nephron Segments of Rat Kidney: Regulation by High Salt Diet and Dehydration2011
Author(s)
Rong Rong, Osamu Ito, Nobuyoshi Mori, Daisuke Ito, Takefumi Mori, Sadayoshi Ito, Kazuhito Totsune, Kazuhiro Takahashi, Masahiro Kohzuki
Organizer
HIGH BLOOD PRESSURE RESEARCH 2011
Place of Presentation
Orlando, FL, US (Oral)
Year and Date
2011-09-24
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