2012 Fiscal Year Final Research Report

Role of a novel pathogen sensor in the pathophysiology of acute renal failure

Research Project

Project/Area Number	23659440
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Kidney internal medicine
Research Institution	Tokyo Medical and Dental University
Principal Investigator	SUGANAMI Takayoshi 東京医科歯科大学, 大学院・医歯学総合研究科, 寄附講座教授 (50343752)
Co-Investigator(Renkei-kenkyūsha)	瀬藤光利浜松医科大学, 分子イメージング先端研究センター, 教授 (20302664) 山崎晶九州大学, 生体防御医学研究所, 教授 (40312946)
Project Period (FY)	2011 – 2012
Keywords	腎虚血再灌流障害 / マクロファージ / 急性腎不全 / 炎症
Research Abstract	Accumulating evidence suggests that pathogen sensors such as TLRs and C-type lectin families are capable of sensing endogenous ligands released from damaged and stressed cells and tissues, thereby inducing sterile inflammation. Here we demonstrate that macrophage-inducible C-typelectin (Mince) is involved in the pathophysiology of renal ischemia-reperfusion injury, an experimental model of acute renal failure. Our data also suggest that Mincle is mainly expressed in proinflammatory macrophages that infiltrate into the damaged kidney.

(5 results)