2013 Fiscal Year Final Research Report
Analysis of inhibitory derivatives for parathyroid gland hormone secretion
Project/Area Number |
23659444
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Kidney internal medicine
|
Research Institution | Foundation for Biomedical Research and Innovation |
Principal Investigator |
IMURA AKIHIRO 公益財団法人先端医療振興財団, その他部局等, 研究員 (60362513)
|
Project Period (FY) |
2011 – 2013
|
Keywords | PTH / Klotho / FGF23 / glucronide |
Research Abstract |
Over half patients with renal failure suffer hyperparathyroidism(HPT). HPT leads to severe osteoporotic state. Recently, a CaR agonist, cinacalcet has been developed to suppress parathyroid gland. In contrast, aKlotho and FGF23 are both essential for regulating PTH secretion. We addressed the principle that aKlotho contributes to PTH secretion and then surveyed the inhibitory chemicals. Screening study revealed estron glucuronide and its derivatives are candidates for suppression of PTH secretion. These data would be seeds for PTH inhibitory drugs based on aKlotho structure.
|
-
[Journal Article] Reduced renal α-Klotho expression in CKD patients and its effect on renal phosphate handling and vitamin D metabolism2014
Author(s)
Sakan H, Nakatani K, Asai O, Imura A, Tanaka T, Yoshimoto S, Iwamoto N, Kurumatani N, Iwano M, Nabeshima Y, Konishi N, Saito Y
-
Journal Title
PLoS One (eCollection 2014)
Volume: 23;9(1)
Pages: e86301
DOI
-
-
-
-
-
[Journal Article] Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary Calcium excretion2012
Author(s)
Asai O, Nakatani K, Tanaka T, Sakan H, Imura A, Yoshimoto S, Samejima K, Yamaguchi Y, Matsui M, Akai Y, Konishi N, Iwano M, Nabeshima Y, Saito Y
-
Journal Title
Kidney Int
Volume: 81(6)
Pages: 539-47
-
[Journal Article] Circulating levels of soluble alpha-Klotho are markedly elevated in human umbilical cord blood2011
Author(s)
Ohata Y, Arahori H, Namba N, Kitaoka T, Hirai H, Wada K, Nakayama M, Michigami T, Imura A, Nabeshima Y, Yamazaki Y, Ozono K
-
Journal Title
J CIin Endocrinol Metab
Volume: 96(6)
Pages: E943-7
-
-
-
-
[Presentation]2012
Organizer
第360回つくば分子生命科学セミナー
Place of Presentation
茨城
Year and Date
20121000
-
-
-
-
-
-
-
-
-