2012 Fiscal Year Final Research Report
Sweet Tase Receptor Expressed in Pancreatic β-cells: PotentialTherapeutic Target
| Project/Area Number |
23659466
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Gunma University |
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Principal Investigator |
KOJIMA Itaru 群馬大学, 生体調節研究所, 教授 (60143492)
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| Project Period (FY) |
2011 – 2012
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| Keywords | インスリン / β細胞 / 甘味受容体 / アポトーシス |
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| Research Abstract |
The sweet taste receptor expressed in pancreatic β-cells is activated by sugars including glucose and fructose. It is also activated by various sweeteners. We showed that sweeteners bind to different portion of the receptor and generate different sets of intracellular messengers. In the present study, we examined the effects of four sweeteners, sucralose, acesulfame K, saccharin and glycyrrhitin, in β-cells and determined which ligand is useful as a stimulant of insulin secretion. The results show that sucralose effectively stimulates insulin secretion and also protects β-cells from apoptosis.
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