2013 Fiscal Year Final Research Report
The regulatory mechanisms of brown adipose tissue by novel adipokine chemerin
| Project/Area Number |
23659477
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Kobe University |
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Principal Investigator |
TAKAHASHI Yutaka 神戸大学, 医学(系)研究科(研究院), 講師 (70301281)
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| Co-Investigator(Kenkyū-buntansha) |
IGUCHI Genzo 神戸大学医学部附属病院, 糖尿病内分泌内科, 助教 (60346260)
FUKUOKA Hidenori 神戸大学医学部附属病院, 糖尿病内分泌内科, 助教 (80622068)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ケマリン / アディポカイン |
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| Research Abstract |
We previously identified chemerin as a novel adipokine that regulates glucose homeostasis (FEBS letters 2008). We have reported that chemerin-deficient mice are glucose intolerant irrespective of exhibiting reduced macrophage accumulation in adipose tissue. The glucose intolerance was mainly due to increased hepatic glucose production and impaired insulin secretion. Expression of MafA, a pivotal transcriptional factor for beta-cell function, was downregulated and rescue of MafA expression restored GSIS, indicating that chemerin regulates beta-cell function via maintaining MafA expression (Scientific Reports 2011). We further demonstrated that serum chemerin concentrations are decreased in patients with T2DM (EJ 2013). In addition, we have clarified a novel regulatory pathway of BAT function in adaptive thermogensis by chemerin.
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[Journal Article] Involvement of PIT-1-reactive cytotoxic T lymphocytes in anti-PIT-1 antibody syndrome2014
Author(s)
Bando H, Iguchi G, Fukuoka H, Yamamoto M, Matsumoto R, Hidaka-Takeno R, Okimura Y, Matsumoto R, Suda K, Nishizawa H, Takahashi M, Toji K, Takahashi Y
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Journal Title
J Clin Endocrinol Metab
Volume: (in press)
Peer Reviewed
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[Journal Article] A missense single-nucleotide polymorphism in the sialic acid acetyl esterase gene is associated with anti-PIT-1 antibody syndrome2014
Author(s)
Yamamoto M, Iguchi G, Bando H, Fukuoka H, Suda K, Takahashi M, Nishizawa H, Matsumoto R, Tojo K, Mokubo A, Ogata T, Takahashi Y
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Journal Title
Endocrine J
Volume: (Epub ahead of print)
Peer Reviewed
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[Journal Article] A PROP1-binding factor, AES cloned by yeast two-hybrid assay represses PROP1-induced Pit-1 gene expression2013
Author(s)
Sugiyama Y, Ikeshita N, Shibahara H, Yamamoto D, Kawagishi M, Iguchi G, Iida K, Takahashi Y, Kaji H, Chihara K, Okimura Y
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Journal Title
Mol Cell Endocrinol
Volume: 376
Pages: 93-8
Peer Reviewed
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[Journal Article] The prevalence of IgG4-related hypophysitis in 170 consecutive patients with hypopituitarism and/or central diabetes insipidus and review of the literature2013
Author(s)
Bando H, Iguchi G, Fukuoka H, Taniguchi M, Yamamoto M, Matsumoto R, Suda K, Nishizawa H, Takahashi M, Kohmura E, Takahashi Y
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Journal Title
Eur J Endocrinol
Volume: 170
Pages: 161-72
Peer Reviewed
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[Journal Article] Nonalcoholic fatty liver disease in adult hypopituitary patient with growth hormone deficiency and the impact of growth hormone replacement therapy2012
Author(s)
Nishizawa H, Iguchi G, Murawaki A, Fukuoka H, Hayashi H, Kaji H, Yamamoto M, Suda K, Takahashi M, Seo Y, Yano Y, Kitazawa R, Kitazawa S, Koga M, Okimura Y, Chihara K, Takahashi Y
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Journal Title
Eur J Endocrinol
Volume: 167
Pages: 67-74
Peer Reviewed
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[Journal Article] Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans2012
Author(s)
Nishizawa S, Handayaningsih AE, Iguchi G, Cho Y, Takahashi M, Yamamoto M, Suda K, Kasahara K, Fumihiko H, Yamanouchi K, Nishihara M, Seino S, Takahashi SI, Takahashi Y
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Journal Title
Growth Hormone and IGF-I Research
Volume: 22
Pages: 64-68
Peer Reviewed
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[Journal Article] Chemerin regulates β-cell function in mice2011
Author(s)
Takahashi M, Okimura Y, Iguchi G, Nishizawa H, Yamamoto M, Suda K, Kitazawa R, Fujimoto W, Takahashi K, Zolotaryov FN, Hong KS, Kiyonari H, Abe T, Kaji H, Kitazawa S, Kasuga M, Chihara K, Takahashi Y
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Journal Title
Scientific Reports
Volume: 1
Pages: 123
DOI
Peer Reviewed
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[Journal Article] Reactive oxygen species play an essential role in IGF-I signaling and IGF-I-induced myocyte hypertrophy in C2C12 myocytes2011
Author(s)
Handayaningshi AE, Iguchi G, Fukuoka H, Nishizawa H, Takahashi M, Yamamoto M, Herningtyas HE, Okimura Y, Kaji H, Chihara K, Seino S, Takahashi Y
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Journal Title
Endocrinology
Volume: 152
Pages: 912-21
Peer Reviewed
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[Journal Article] A case of primary aldosteronism caused by multiple adrenocortical macronodules2011
Author(s)
Hashimoto N, Kawamura Y, Nakamura T, Murawaki A, Nishiumi T, Hirota Y, Sakagushi K, Kurahashi T, Miyake H, Fujisawa M, Sasano H, Takahashi Y
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Journal Title
Intern Med
Volume: 50
Pages: 585-90
Peer Reviewed
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[Journal Article] Adult combined GH, prolactin and TSH deficiency associated with circulating PIT-1 antibody in humans2011
Author(s)
Yamamoto M, Iguchi G, Takeno R, Okimura Y, Sano S, Takahashi M, Nishizawa H, Handayaningshi AE, Fukuoka H, Tobita M, Saitoh T, Tojo T, Mokubo A, Morinobu A, Iida K, Kaji H, Seino S, Chihara K, Takahashi Y
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Journal Title
J Clin Invest
Volume: 121
Pages: 113-9
Peer Reviewed
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[Presentation] Novel autoimmune polyendocrine syndrome : Adult combined GH, prolactin and TSH deficiency associated with circulating PIT-1 antibody2011
Author(s)
Takahashi Y, Yamamoto M, Iguchi G, Takeno R, Okimura Y, Sano T, Takahashi M, Nishizawa H, Handayaningsih AE, Tojo K, Mokubo A, Iida K, Kaji K, Chihara K
Organizer
The 93th Annual Meeting of the Endocrine Society
Place of Presentation
Boston
Year and Date
2011-06-04
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