• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2012 Fiscal Year Final Research Report

Elucidation of energy metabolic pathways in hormone-dependent cancers by utilizing cellular and in vivo imaging analyses

Research Project

  • PDF
Project/Area Number 23659479
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Endocrinology
Research InstitutionSaitama Medical University

Principal Investigator

HORIE Kuniko  埼玉医科大学, 医学部, 准教授 (90261982)

Co-Investigator(Kenkyū-buntansha) IKEDA Kazuhiro  埼玉医科大学, 医学部, 講師 (30343461)
Co-Investigator(Renkei-kenkyūsha) INOUE Satoshi  東京大学, 医学部, 特任教授 (40251251)
Project Period (FY) 2011 – 2012
Keywords性ホルモン / がん / イメージング / エネルギー代謝
Research Abstract

In order to reveal characterize metabolic pathways involved in the proliferation and progression of hormone-dependent cancers such as breast and prostate cancers, cell models of hormone-naive and hormone-resistant cancer cellsexpressing fluorescent reporters were generated. A microscopic imaging system for the observation of these cancer cells was developed in response to environmental alterationsby monitoring reporter fluorescence. Inoculation of cancer cells stably expressing luciferase reporter genes into nude mice was performed and the dynamics of cancer cell proliferation and metastasis were investigated based on in vivo imaging analysis. Expression and transcriptional regulation of metabolic genes in hormone-dependent cancer cells were analyzed molecular biologically. Taken together, the present study identified novel molecular targets that can be applied to the diagnosis, therapy, and prevention of hormone-dependent cancers.

  • Research Products

    (9 results)

All 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Genome-wide integrated analyses of androgen receptor signaling in prostate cancer based on high-throughput technology2013

    • Author(s)
      Horie-Inoue K, Inoue S
    • Journal Title

      Curr Drug Targets

      Volume: 14(4) Pages: 472-480

    • DOI

      DOI:10.2174/1389450111314040008.

    • Peer Reviewed
  • [Journal Article] Association of double-positive FOXA1 and FOXP1 immunoreactivities with favorable prognosis of tamoxifen-treated breast cancer patients.2012

    • Author(s)
      Ijichi N, Shigekawa T, Ikeda K, Horie-Inoue K, Shimizu C, Saji S, Aogi K, Tsuda H, Osaki A, Saeki T, Inoue S.
    • Journal Title

      Horm Cancer

      Volume: 3(4) Pages: 147-159

    • DOI

      DOI:10.1007/s12672-012-0111-0

    • Peer Reviewed
  • [Journal Article] TACC2 is an androgen-responsive cell cycle regulator promoting androgen-mediated and castration-resistant growth of prostate cancer.2012

    • Author(s)
      Takayama K, Horie-Inoue K, Suzuki T, Urano T, Ikeda K, Fujimura T, Takahashi S, Homma Y, Ouchi Y, Inoue S.
    • Journal Title

      Mol Endocrinol.

      Volume: 26(5) Pages: 748-761

    • DOI

      DOI:10.1210/me.2011-1242

    • Peer Reviewed
  • [Journal Article] Forkhead box transcription factor, forkhead box A1, shows negative association with lymph node status in endometrial cancer, and represses cell proliferation and migration of endometrial cancer cells2012

    • Author(s)
      Abe Y, Ijichi N, Ikeda K, Kayano H, Horie-Inoue K, Takeda S, Inoue S
    • Journal Title

      Cancer Sci

      Volume: 103(4) Pages: 806-812

    • DOI

      DOI:10.1111/j.1349-7006.2012.02201.x.

    • Peer Reviewed
  • [Journal Article] FOXP1, an estrogen-inducible transcription factor, modulates cell proliferation in breast cancer cells and 5-year recurrence-free survival of patients with tamoxifen-treated breast cancer2011

    • Author(s)
      Shigekawa T, Ijichi N, Ikeda K, Horie-Inoue K, Shimizu C, Saji S, Aogi K, Tsuda H, Osaki A, Saeki T, Inoue S
    • Journal Title

      Horm Cancer

      Volume: 2(5) Pages: 286-297.

    • DOI

      DOI:10.1007/s12672-011-0082-6

    • Peer Reviewed
  • [Presentation] Systemic screening of microRNAs nad their targets for breast cancer cells using a comprehensive lentiviral microRNA library and microarrays.2012

    • Author(s)
      Horie-Inoue K, Yamaga R, Okamoto K, Ikeda K, Inoue S.
    • Organizer
      Keystone Symposia, Non-coding RNAs
    • Place of Presentation
      Snowbird, Utah, USA.
    • Year and Date
      20120332-0405
  • [Presentation] Cytochrome c oxidase subunit 7a related polypeptide COX7RP is an estrogen target gene that plays a role in the OXPHOS pathway.2011

    • Author(s)
      Ikeda K, Horie-Inoue K, Inoue S
    • Organizer
      5th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia), 8th Conference of Asian Society for Mitochondrial Research and Medicine (ASMRM), 11th Conference of Japanese Society of Mitochondrial Research and Medicine (J-mit)
    • Place of Presentation
      鹿児島市
    • Year and Date
      20110831-0904
  • [Presentation] Identification of androgen-regulated cytochrome coxidase-related genes in hormone-sensitive prostate cancer cells through RNA-sequencing and systemic chromatin immunoprecipitation analysis2011

    • Author(s)
      Horie-Inoue K, Takayama K, Ikeda K, Suzuki Y, Inoue S
    • Organizer
      Mitochondrial Assembly & Dynamics in Health, Disease & Aging, FASEB Summer Research Conferences
    • Place of Presentation
      Steamboat Springs, Colorado, USA.
    • Year and Date
      20110717-22
  • [Remarks]

    • URL

      http://www.saitama-med.ac.jp/genome/Div02_GRST/index.html

URL: 

Published: 2014-09-25   Modified: 2016-01-14  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi