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2012 Fiscal Year Final Research Report

Role of CXCL14 as a sensor for behavior-stimulating substance

Research Project

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Project/Area Number 23659481
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Endocrinology
Research Institution公共財団法人東京都医学総合研究所 (2012)
Tokyo Metropolitan Organization for Medical Research (2011)

Principal Investigator

HARA Takahiko  公共財団法人東京都医学総合研究所, 生体分子先端研究分野, 副参事研究員 (80280949)

Project Period (FY) 2011 – 2012
Keywords内分泌学
Research Abstract

In order to understand the role of CXCL14, I attempted to identify CXCL14 receptor molecules. As a result of GPCR knockdown experiments and cDNA rescue experiments using THP-1 cell line, I found that CXCL14 binds to CXCR4 with high affinity, and that another orphan GPCR (GPR14) was indispensable for the CXCL14-mediated signal transduction. CXCL14 cross-inhibited the chemotactic activity of CXCL12. GPR14- was abundantly expressed in mucosal tissues along with CXCL14. Therefore, GPR-14-interacting molecules could involved in the feeding behavior control by CXCL14.

  • Research Products

    (10 results)

All 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (4 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis.2013

    • Author(s)
      K. Tanegashima, K. Suzuki, Y. Nakayama, K.Tsuji, A. Shigenaga, A. Otaka, and T. Hara.
    • Journal Title

      FEBS Letters

      Volume: 587 Pages: 1731-1735

    • DOI

      doi:10.1016/j.febslet.2013.04.046

    • Peer Reviewed
  • [Journal Article] Tanegashima. Pleiotropic functions of the CXC-type chemokine CXCL14 in mammals.2012

    • Author(s)
      T. Hara and K
    • Journal Title

      J. Biochem

      Volume: 151 Pages: 469-476

    • DOI

      doi:10.1093/jb/mvs030

    • Peer Reviewed
  • [Journal Article] CXCL142012

    • Author(s)
      種子島幸祐, 原 孝彦
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 57 Pages: 330-335

  • [Journal Article] Application of N to C- or C to N-directed sequential native chemical ligation to the preparation of CXCL14 analogs and their biological evaluation.2011

    • Author(s)
      K. Tsuji, A. Shigenaga, Y. Sumikawa, K. Tanegashima, K. Sato, K. Aihara, T. Hara, and A. Otaka
    • Journal Title

      Bioorg. Med. Chem

      Volume: 19 Pages: 4014-4020

    • DOI

      doi:10.1016/j.bmc.2011.05.018

    • Peer Reviewed
  • [Presentation] CXCL12-CXCR4軸を介した幹細胞誘引の調節因子.2013

    • Author(s)
      原 孝彦, 種子島幸祐, 鈴木健司, 辻耕平, 重永 章, 長澤丘司, 大高 章
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      20130321-23
  • [Presentation] ケモカインCXCL14とその受容体を介した脂肪蓄積制御2012

    • Author(s)
      種子島幸祐, 鈴木健司,原 孝彦
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      京都
    • Year and Date
      20121010-11
  • [Presentation] CXCL14 acts as a natural inhibitor for CXCL12/CXCR4 signaling. Gordon Research Conference2012

    • Author(s)
      T. Hara, K. Tanegashima, K. Tsuji, K. Suzuki, Y.Nakayama, A. Shigenaga, T. Nagasawa, M. Mori, and A. Otaka
    • Organizer
      Chemotactic Cytokines
    • Place of Presentation
      Il Ciocco, Italy
    • Year and Date
      20120527-0601
  • [Presentation] Identification of G protein coupled receptors which constitute the functional CXCL14 receptors.2011

    • Author(s)
      鈴木健司, 種子島幸祐, 中山由紀, 重永 章, 大高 章, 長澤丘司, 森 正明, 原 孝彦
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20111213-16
  • [Remarks]

    • URL

      http://www.igakuken.or.jp/stem-cell/

  • [Patent(Industrial Property Rights)] CXCR4活性阻害ペプチド及びその用途2011

    • Inventor(s)
      原 孝彦, 大高 章, 重永 章, 種子島幸祐
    • Industrial Property Rights Holder
      原 孝彦, 大高 章, 重永 章, 種子島幸祐
    • Industrial Property Number
      特許,2011-251758
    • Filing Date
      2011-11-17

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Published: 2014-08-29   Modified: 2014-10-07  

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