2012 Fiscal Year Final Research Report
Analysis of relationship between nuclear segmentation and gene expression using neutrophils and ATL cells
| Project/Area Number |
23659485
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UCHIMARU Kaoru 東京大学, 医科学研究所, 准教授 (60251203)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 好中球 / ATL / エピジェネティクス / メチル化 / 遺伝子発現 |
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| Research Abstract |
Multi-step oncogenesis of HTLV-1 infected cells to Adult T-cell leukemia well reflected on the cell surface expression of CD7 and CADM1, tumor suppressor gene originally detected in lung cancer. It is suggested that alteration of gene expression in this process is regulated by methylation of the gene. We can detect intermediate cells of oncogenesis even in the peripheral blood of asymptomatic carriers.
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Research Products
(14 results)
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[Journal Article] The CD3 versus CD7 plot in multicolor flow cytometry reflects progression of disease stage in patients infected with HTLV-I2013
Author(s)
Kobayashi S, Tian Y, Ohno N, Yuji K, Ishigaki T, Isobe M, Ohfuchi-Tsuda M, Oyaizu N, Watanabe E, Watanabe N, Tani K, Tojo A and Uchimaru K
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Journal Title
PLoS One
Volume: 8
Pages: e53728
DOI
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[Journal Article] Polycomb- Mediated Loss of miR-31 Activates NIK- dependent NF-kappa B Pathway in Adult T-cell Leukemia and Other Cancers2012
Author(s)
Makoto Yamagishi, Kazumi Nakano, Ariko Miyake, Tadanori Yamochi, Yayoi Kagami, Akihisa, Tsutsumi, Yuka Matsuda, Aiko Sato-Otsubo, Satsuki Muto, Atae Utsunomiya, Kazunari Yamaguchi, Kaoru Uchimaru, Seishi Ogawa, and Toshiki Watanabe
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Journal Title
Cancer cell
Volume: 21(1)
Pages: 121-135
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[Journal Article] Adult T-cell leukemia cells are characterized by abnormalities of Helios expression that promote T-cell growth
Author(s)
Asanuma S, Yamagishi M, Kawanami Ka, Nakano K, Sato-Otsubo A, Muto S, Sanada M, Yamochi T, Kobayashi S, Utsunomiya A, Iwanaga M, Yamaguchi K, Uchimaru K, Ogawa S and Watanabe T
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Journal Title
Cancer Sci
Volume: (in press)
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[Presentation] Molecular Hallmarks of Adult T cell Leukemia: miRNA, Epigenetics, and Emerging Signaling Abnormalities2012
Author(s)
Makoto Yamagishi, Ryutaro Takahashi, Kazumi Nakano, Satomi Asanuma, Atae Utsunomiya, Kazunari Yamaguchi, Kaoru Uchimaru, Seishi Ogawa, and Toshiki Watanabe
Organizer
第74回日本血液学会学術集会
Place of Presentation
京都
Year and Date
20120000
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