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2012 Fiscal Year Final Research Report

Analysis of relationship between nuclear segmentation and gene expression using neutrophils and ATL cells

Research Project

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Project/Area Number 23659485
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Hematology
Research InstitutionThe University of Tokyo

Principal Investigator

KITAMURA Toshio  東京大学, 医科学研究所, 教授 (20282527)

Co-Investigator(Kenkyū-buntansha) UCHIMARU Kaoru  東京大学, 医科学研究所, 准教授 (60251203)
Project Period (FY) 2011 – 2012
Keywords好中球 / ATL / エピジェネティクス / メチル化 / 遺伝子発現
Research Abstract

Multi-step oncogenesis of HTLV-1 infected cells to Adult T-cell leukemia well reflected on the cell surface expression of CD7 and CADM1, tumor suppressor gene originally detected in lung cancer. It is suggested that alteration of gene expression in this process is regulated by methylation of the gene. We can detect intermediate cells of oncogenesis even in the peripheral blood of asymptomatic carriers.

  • Research Products

    (14 results)

All 2013 2012 2011 Other

All Journal Article (4 results) Presentation (9 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] The CD3 versus CD7 plot in multicolor flow cytometry reflects progression of disease stage in patients infected with HTLV-I2013

    • Author(s)
      Kobayashi S, Tian Y, Ohno N, Yuji K, Ishigaki T, Isobe M, Ohfuchi-Tsuda M, Oyaizu N, Watanabe E, Watanabe N, Tani K, Tojo A and Uchimaru K
    • Journal Title

      PLoS One

      Volume: 8 Pages: e53728

    • DOI

      DOI:10.1371/journal.pone.0053728

  • [Journal Article] Polycomb- Mediated Loss of miR-31 Activates NIK- dependent NF-kappa B Pathway in Adult T-cell Leukemia and Other Cancers2012

    • Author(s)
      Makoto Yamagishi, Kazumi Nakano, Ariko Miyake, Tadanori Yamochi, Yayoi Kagami, Akihisa, Tsutsumi, Yuka Matsuda, Aiko Sato-Otsubo, Satsuki Muto, Atae Utsunomiya, Kazunari Yamaguchi, Kaoru Uchimaru, Seishi Ogawa, and Toshiki Watanabe
    • Journal Title

      Cancer cell

      Volume: 21(1) Pages: 121-135

  • [Journal Article] Leukemic T cells are specifically enriched in a unique CD3^dimCD7^low subpopulation of CD4^+ T cells in acute-type adult T cell leukemia2011

    • Author(s)
      Tian Y, Kobayashi S, Ohno N, Isobe M, Tsuda M, Tani K, Zaike Y, Watanabe N, Tojo A and Uchimaru K
    • Journal Title

      Cancer Sci

      Volume: 102(3) Pages: 569-577

  • [Journal Article] Adult T-cell leukemia cells are characterized by abnormalities of Helios expression that promote T-cell growth

    • Author(s)
      Asanuma S, Yamagishi M, Kawanami Ka, Nakano K, Sato-Otsubo A, Muto S, Sanada M, Yamochi T, Kobayashi S, Utsunomiya A, Iwanaga M, Yamaguchi K, Uchimaru K, Ogawa S and Watanabe T
    • Journal Title

      Cancer Sci

      Volume: (in press)

  • [Presentation] 患者検体を用いたCD7とTSLC1/CADM1のFACS解析はATLの多段階発癌を反映する2012

    • Author(s)
      小林誠一郎、中野和民、渡辺恵理、石垣知寛、大野伸広、渡辺信和、東條有伸、内丸薫
    • Organizer
      第1回ATLシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      20120000
  • [Presentation] TSLC1/CD7を用いた造血細胞移植後のATL細胞のモニタリング2012

    • Author(s)
      石垣知寛、小林誠一郎、大野伸広、渡辺恵理、田野崎隆二、渡辺信和、東條有伸、内丸薫
    • Organizer
      第5回HTLV-1研究会
    • Place of Presentation
      東京
    • Year and Date
      20120000
  • [Presentation] 同種造血幹細胞移植を見据えたATLの治療戦略:その後方視的解析2012

    • Author(s)
      大野伸広、田野崎隆二、小林誠一郎、石垣知寛、渡辺信和、内丸薫
    • Organizer
      第5回HTLV-1研究会
    • Place of Presentation
      東京
    • Year and Date
      20120000
  • [Presentation] Molecular Hallmarks of Adult T cell Leukemia: miRNA, Epigenetics, and Emerging Signaling Abnormalities2012

    • Author(s)
      Makoto Yamagishi, Ryutaro Takahashi, Kazumi Nakano, Satomi Asanuma, Atae Utsunomiya, Kazunari Yamaguchi, Kaoru Uchimaru, Seishi Ogawa, and Toshiki Watanabe
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      20120000
  • [Presentation] CD7 vs CADM1 in FACS reflects multi-step oncogenesis of ATL and discriminates HTLV-1 infected cells2012

    • Author(s)
      Seiichro Kobayashi, Eri Watanabe, Tomohiro Ishigaki, Nobuhiro Ohno, Koichiro Yuji, Yukio Tsukada, Akihiro Ohmoto, Naoki Shimada, Nobukazu Watanabe, Arinobu Tojo and Kaoru Uchimaru
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      20120000
  • [Presentation] CD3とCD7の展開による急性型ATL細胞の同定:治療後のCD3dimCD7(-)分画のクローナリティ解析2012

    • Author(s)
      大野伸広、小林誠一郎、渡辺信和、石垣知寛、湯地晃一郎、東條有伸、内丸薫
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      20120000
  • [Presentation] CD3 vs CD7 plot in multi-colour FACS reflects progression of disease stage of HTLV-1 infected patients2011

    • Author(s)
      Kobayashi S, Tian Y, Ohno N, Isobe M, Tsuda M, Zaike Y, Watanabe N, Tani K, Tojo A Uchimaru K
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      20110000
  • [Presentation] フローサイトメトリーによるフェノタイプ解析を用いた、急性型ATLの末梢血腫瘍細胞数の評価2011

    • Author(s)
      石垣知寛、在家裕司、小林誠一郎、大野伸広、内丸薫、渡辺信和、小柳津直樹、東條有伸、中内啓光
    • Organizer
      第4回HTLV-1研究会
    • Place of Presentation
      東京
    • Year and Date
      20110000
  • [Presentation] マルチカラーFACSにおけるCD3とCD7の展開はHTLV-1感染患者の病期の進行を反映する2011

    • Author(s)
      小林誠一郎、田亜敏、大野伸広、湯地晃一郎、石垣知寛、磯部優理、津田真由子、在家裕司、渡辺恵理、渡辺信和、谷憲三朗、東條有伸、内丸薫
    • Organizer
      第4回HTLV-1研究会
    • Place of Presentation
      東京
    • Year and Date
      20110000
  • [Patent(Industrial Property Rights)] 患者検体を用いた HTLV-1 キャリア、成人 T 細胞白血病の発癌過程進行度又 は悪性度の評価法

    • Inventor(s)
      内丸薫、小林誠一郎、渡辺信和
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Number
      特願 2013-034326

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Published: 2014-09-25   Modified: 2015-11-26  

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