2012 Fiscal Year Final Research Report
Reduction of memory Th2 cell pool for the treatment of allergic diseases
| Project/Area Number |
23659496
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
膠原病・アレルギー・感染症内科学
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | メモリーTh2 細胞 / 気管支喘息 / 肺血管リモデリング / IL-25 |
|---|
| Research Abstract |
The characteristics of asthma are mainly mediated by antigen-specific memory Th2 cells and their cytokines including IL-4, IL-5, and IL-13. In this study, we tried to identify cell surface molecules specific for memory Th2 cells by using DNA microarray analysis and retrovirus-mediated signal sequence trap screening. However, unfortunately, we could not identify memory Th2 cell-specific molecules within this research period. On the other hand, we found that prolonged Th2-type immune inflammation in the lung induces the expression of IL-25 and pulmonary arterial remodeling (PAR). Injection of anti-IL-25 antibody inhibited antigen-induced PAR. Lung-specificIL-25 transgenic mice (CC10 IL-25 mice) but not CC10 IL-25 NKT^<-/-> mice spontaneouslydeveloped PAR. These results suggest that prolonged expression of IL-25 in the lung induces PARby NKT cell-dependent mechanisms.
|
-
-
-
[Journal Article] [18F] FDG uptake in proximal muscles assessed by PET/CT reflects both global and local muscular inflammation and provides useful information in the management of patients with polymyositis/dermatomyositis.2013
Author(s)
Tanaka S, Ikeda K, Uchiyama K, Iwamoto T, Sanayama Y, Okubo A, Nakagomi N, Takahashi K, Yokota M, Suto A, Suzuki K, Nakajima H.
-
Journal Title
Rheumatology (Oxford)
Volume: (in press)
Peer Reviewed
-
[Journal Article] Confirming the presence of synovitis with ultrasound improves the accuracy of 2010 ACR/EULAR classification criteria for rheumatoid arthritis.2013
Author(s)
Nakagomi D, Ikeda K, Okubo A, Iwamoto T, Sanayama Y, Takahashi K, Yamagata M, Takatori T, Suzuki K, Takabayashi K, Nakajima H.
-
Journal Title
Arthritis Rheum.
Volume: 65(4)
Pages: 890-8
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
[Presentation] IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation2012
Author(s)
Takahashi K, Kawashima S, Niwa Y, Iwata A, Kobayashi Y, Kagami S, Suto A, Hirose K, Watanabe N, Nakayama T, Nakajima H
Organizer
99th Annual meeting of the The American Assoiciation ofImmunologists
Place of Presentation
Boston, U.S.A.
Year and Date
2012-05-06
-
-
