2011 Fiscal Year Final Research Report
The molecular mechanism of signal transduction of IL-17 receptors
| Project/Area Number |
23659497
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAKAE Susumu 東京大学, 医科学研究所, 特任准教授 (60450409)
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| Co-Investigator(Renkei-kenkyūsha) |
NAMBU Aya 東京大学, 医科学研究所, 特任研究員 (10456197)
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| Project Period (FY) |
2011
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| Keywords | アレルギー学 |
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| Research Abstract |
Five molecules, IL-17RA through IL-17RE, have been identified as members the IL-17 receptor family. However, the molecular mechanism(s) of signal transduction via these molecules is poorly understood. In the study, we attempted to identify adopter molecules that bind directly to the intracellular domains of IL-17 receptors and clarify their pathways of signal transduction downstream of each receptor.
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