2012 Fiscal Year Final Research Report
Development of a novel disease severity marker for the inflammatory bowel diseases.
| Project/Area Number |
23659498
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Niigata University |
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Principal Investigator |
NAKATA Koh 新潟大学, 医歯学総合病院, 教授 (80207802)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Kenji 新潟大学, 医歯学総合病院, 講師 (00303123)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 炎症学 |
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| Research Abstract |
To develop a novel disease severity marker for Crohn's disease and ulceritive colitis, we invesitgated the concentration of IgG type and IgM type GM-CSF autoantibody concentrations in the sera from patients with Crohn's disease(n=44), ulcerative colitis(n=45), and normal subjects(n=43). The concentration of IgG antibody was under the detection limit in most subjects, but the concentration of IgM antibody was significantly higher in Crohn's disease than those in ulcerative disease and normal subjects. No significant correlation was found between the concentration and the disease severity.
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[Journal Article] Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells.2012
Author(s)
Wong WF, Kohu K, Nakamura A, Ebina M, Kikuchi T, Tazawa R, Tanaka K, Kon S, Funaki T. Sugahara-Tobinai A, Looi CY, Endo S, Funayama R, Kurokawa M, Habu S, Ishii N, Fukumoto M, Nakata K, Takai T, Satake M.
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Journal Title
Intern Med.
Volume: 188(11)
Pages: 5408-5420
Peer Reviewed
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[Journal Article] IgM-type GM-CSF Autoantibody is Etiologically a Bystander but Associated with IgG-type Autoantibody Production in Autoimmune Pulmonary Alveolar Proteinosis.2012
Author(s)
Nei T, Urano S, Motoi N, Takizawa J,Kaneko C,Kanazawa H,Tazawa R,Nakagaki K, Akagawa KS,Akasaka K, Ichiwata T Azuma A, Nakata K.
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Journal Title
Am. J. Physiol.
Volume: 302(9)
Pages: L959-964
Peer Reviewed
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[Journal Article] Direct evidence that GM-CSF inhalation improveslung clearance in pulmonary alveolar proteinosis.2012
Author(s)
Ohashi K, Sato A, Takada T, Arai T, Nei T, Kasahara Y, Motoi N, Hojo M, Urano S, Ishii H, Yokoba M, Eda R, Nakayama H, Nasuhara Y, Tsuchihashi Y, Kaneko C, Kanazawa H, Ebina M, Yamaguchi E, Kirchner J, Inoue Y, Nakata K, Tazawa R.
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Journal Title
Respir Med.
Volume: 106(2)
Pages: 284-293
Peer Reviewed
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[Journal Article] Identification of a mechanism for lung inflammation caused by Mycoplasma pneumoniae using a novel mouse model.2011
Author(s)
Saraya T, Nakata K, Nakagaki K, Motoi N, Iihara K, Fujioka Y, Oka T, Kurai D, Wada H, Ishii H,Taguchi H, Kamiya S, Goto H.
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Journal Title
Results in Immunology.
Volume: 1(1)
Pages: 76-87
Peer Reviewed
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[Journal Article] Vaccination with CD133+ melanoma induces specific Th17 and Th1 cell -mediated antitumor reactivity against parental tumor.2011
Author(s)
Miyabayashi T, Kagamu H, Koshio J, Ichikawa K, Baba J, Watanabe S, Tanaka H, Tanaka J, Yoshizawa H, Nakata K, Narita I.
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Journal Title
Cancer Immunol Immunother.
Volume: 60(11)
Pages: 1597-1608
Peer Reviewed
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[Journal Article] Clinical features of secondary pulmonary alveolar proteinosis: pre-mortem cases in Japan.2011
Author(s)
Ishii H, Tazawa R, Kaneko C, Saraya T, Inoue Y, Hamano E, Kogure Y, Tomii K, Terada M, Takada T, Hojo M, Nishida A, Ichiwata T, Trapnell BC, Goto H, Nakata K.
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Journal Title
European Respir. J.
Volume: 37(2)
Pages: 465-468
Peer Reviewed
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[Presentation] Pulmonary Alveolar Proteinosis (PAP) And Inhaled Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) Therapy ?Clinical Features Predicting Recurrence2012
Author(s)
R. Tazawa, T. Arai, T. Takada, Y. Kasahara, Y. Tsuchihashi, T. Nei, M. Hojo, H. Nakayama, M. Yokoba, H. Ishii, R. Eda,Y. Nasuhara, M. Ebina, M. Akira, E. Yamaguchi, Y. Inoue, K. Nakata.
Organizer
American Thoracic Society Annual Meeting.
Place of Presentation
San Francisco , U.S.A.
Year and Date
2012-05-23
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[Presentation] IgM Type GM-CSF Autoantibody is Etiologically a Bystander but May be Involved in Development of IgG Type Autoantibody in Autoimmune Pulmonary Alveolar Proteinosis2012
Author(s)
Nakata K, Nei T, Motoi N, Urano S, Tazawa R, Kanako C, Nakagaki K, Suzuki M,Takizawa J, Azuma A.
Organizer
American Thoracic Society Annual Meeting.
Place of Presentation
San Francisco , U.S.A.
Year and Date
2012-05-23
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[Book] 大学病院などの再生医療を支える細胞プロセッシング室運営マニュアル.2012
Author(s)
井上典子,梶昌美,小神晴美,渡辺真理,関根優,白山早起,藤本陽子,瀧澤淳,牧口智夫,布施一郎,中田光.
Total Pages
142
Publisher
株式会社ウイネット
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