The circadian clocks condition neuronal/endocrine/immune axis

2012 Fiscal Year Final Research Report

• Project/Area Number: 23659499
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: University of Yamanashi
• Principal Investigator: NAKAO Atsuhito 山梨大学, 大学院・医学工学総合研究部, 教授 (80317445)
• Project Period (FY): 2011 – 2012
• Keywords: 体内時計 / 神経 / 内分泌 / 免疫

Research Abstract

This study showed that the time of day-dependent variation in the skin allergic reaction observed in the sham-operated mice was absent in the mice with the physical ablation of the SCN. In addition, the time of day-dependent variation in the skin allergic reaction was absent in the mice with specific deletion of the Clock gene in mast cells. These results suggest the circadian clocks drive the daily rhythms in the skin allergic reaction by mediating temporal regulation of the nervous/endocrine/immune systems.

Research Products

• [Journal Article] Mast cells play a key role in host defense against herpes simplex virus infection through TNF-a and IL-6 production (2013)
  • Author(s): Aoki R, Kawamura T, Goshima F, Ogawa Y, Nakaw S, Nakao A, Moriishi K, Nishiyama Y, Shimada S
  • Journal Title: J Invest Dermatol
  • Peer Reviewed
• [Journal Article] Cermakian N, Lange T, Golombek D, Sarkar D, Nakao A, Shibata S, Mazzoccoli G (2013)
  • Author(s): Cermakian N, Lange T, Golombek D, Sarkar D, Nakao A, Shibata S, Mazzoccoli G
  • Journal Title: Chronobiol Int
  • Peer Reviewed
• [Journal Article] Endogenous TGF-ss activity limits TSLP expression in the intervertebral disc tissue by suppressing NF-kB activation (2013)
  • Author(s): Zhu Y, Ohba T, Ando T, Fujita K, Koyama K, Nakamura Y, Katoh R, Haro H, Nakao A
  • Journal Title: J Orthop Res
  • Peer Reviewed
• [Journal Article] Biological clock dysfunction exacerbates contact hypersensitivity in mice (2013)
  • Author(s): Takita E, Yokota S, Tahara Y, Hirao A, Aoki N, Nakamura Y, Nakao A, Shibata S
  • Journal Title: Brit J Dermatol Volume: 168(1) Pages: 39-46
  • Peer Reviewed
• [Journal Article] Grape seed extract from "Koshu" cultivar antagonizes dioxin-induced aryl hydrocarbon receptor activation (2012)
  • Author(s): Sugiyama T, Kitamura M, Sugita K, Hisamoto M, Okuda T, Nakao A
  • Journal Title: Am J Enol Viticult
  • Peer Reviewed
• [Journal Article] Dietary resveratrol prevents the development of food allergy in mice (2012)
  • Author(s): Okada Y, Oh-oka K, Nakamura Y, Ishimaru K, Matsuoka S, Okumura K, Ogawa H, Hisamoto M, Okuda T, Nakao A
  • Journal Title: PLoS One Volume: 7(9) Pages: e44338
  • Peer Reviewed
• [Journal Article] Severe dermatitis with loss of epidermal langerhans cells in human and mouse zinc deficiency (2012)
  • Author(s): Kawamura T, Ogawa Y, Nakamura Y, Nakamizo S, Ohta T, Nakano H, Kabashima K, Katayama I, Koizumi S, Kodama T, Nakao A, Shimada S
  • Journal Title: J Clin Invest Volume: 122(2) Pages: 722-732
  • Peer Reviewed
• [Journal Article] Transforming growth factor-ss(1) promotes nasal mucosal mast cell chemotaxis in murine experimental allergic rhinitis (2012)
  • Author(s): Ouyang Y, Nakao A, Han D, Zhang L
  • Journal Title: ORL J Otorhinolaryngol Relat Spec Volume: 74(3) Pages: 117-123
  • Peer Reviewed
• [Presentation] 教育講演]TSLPとアレルギー (2012)
  • Author(s): 中尾篤人
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2012-11-30
• [Presentation] マスト細胞の内在時計による即時型皮膚反応の日内変動の調節 (2012)
  • Author(s): 中村勇規,中尾篤人,柴田重信
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2012-11-29
• [Presentation] マスト細胞の内在時計による即時型皮膚反応の日内変動の調節 (2012)
  • Author(s): 中村勇規,中尾篤人,柴田重信
  • Organizer: 第14回応用薬理シンポジウム
  • Place of Presentation: ベルクラシック甲府(甲府市)
  • Year and Date: 2012-09-03
• [Presentation] アレルギーと体内時計 (2012)
  • Author(s): 中尾篤人
  • Organizer: 第14回応用薬理シンポジウム
  • Place of Presentation: ベルクラシック甲府(甲府市)
  • Year and Date: 2012-09-03