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2012 Fiscal Year Final Research Report

Analysis of pathogenesis of IgG4-related disease

Research Project

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Project/Area Number 23659503
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionKanazawa Medical University

Principal Investigator

UMEHARA Hisanori  金沢医科大学, 医学部, 教授 (70247881)

Co-Investigator(Kenkyū-buntansha) TAKEGAMI Tsutomu  金沢医科大学, 総合医学研究所, 教授 (10113490)
TOMOSUGI Naohisa  金沢医科大学, 総合医学研究所, 教授 (80155580)
Co-Investigator(Renkei-kenkyūsha) FUKUSHIMA Toshihiro  金沢医科大学, 医学部, 准教授 (60251998)
MASAKI Yasufumi  金沢医科大学, 医学部, 准教授 (40238895)
KAWANAMI Takafumi  金沢医科大学, 医学部, 講師 (20350762)
FUJITA Yoshimasa  金沢医科大学, 医学部, 講師 (70450880)
ISHIGAKI Yasuto  金沢医科大学, 総合医学研究所, 講師 (20232275)
SAWAKI Toshioki  金沢医科大学, 医学部, 助教 (90534694)
SAKAI Tomoyuki  金沢医科大学, 医学部, 助教 (90566902)
Project Period (FY) 2011 – 2012
Keywords膠原病学
Research Abstract

IgG4-related disease (IgG4-RD) is a new disease concept first recognized in the 21st century. The condition is characterized by elevated serum IgG4 values and marked IgG4-positive plasma cell infiltration of affected lesions. Pathogenesis of IgG4-RD is still unclear. We have done DNA microarray and proteomics analysis to investigate its pathogenesis.

  • Research Products

    (14 results)

All 2013 2012 2011

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (3 results) Book (1 results)

  • [Journal Article] Comprehensive Diagnostic Criteria(CDC criteria) for IgG4-related disease(IgG4-RD)2012

    • Author(s)
      Umehara,H.,K.Okazaki,Y.Masaki,M.Kawano,M.Yamamoto,T.Saeki,S.Matsui,T.他 and all Japan IgG4 team
    • Journal Title

      Mod.Rheum.

      Volume: 22(1) Pages: 21-30

    • Peer Reviewed
  • [Journal Article] Research Program for Intractable Diseaseby Ministry of Health,Laborand Welfare (MHLW) Japan G4 team.2012

    • Author(s)
      Umehara,H.,K.Okazaki,Y.Masaki,M.Kawano,M.Yamamoto,T.Saeki,S.Matsui,T.Sumida,T.Mimori,Y.Tanaka,K.他andthe
    • Journal Title

      ModRheum

      Volume: 22(1) Pages: 1-14

    • Peer Reviewed
  • [Journal Article] A new clinical entity:IgG4-related disease(IgG4-RD) discovered in the 21st century2012

    • Author(s)
      Umehara,H
    • Journal Title

      Intern Med

      Volume: 51(8) Pages: 821-822

    • Peer Reviewed
  • [Journal Article] Henoch-Schonlein purpura nephritis in a patient with IgG4-related disease Apossible association.2012

    • Author(s)
      ItoK,Yamada K,Mizushima I,Aizu M,Fujii H,Mizutomi K,Matsumura M,Hayashi K,Yamagish M,Umehara H,Yamaguchi Y,Nagata M,and Kawano M.
    • Journal Title

      Clin Nephrol

    • Peer Reviewed
  • [Journal Article] IgG4-Related Disease:Recommendations for the Nomenclature of this Condition and itsI ndividual Organ System Manifestations.2012

    • Author(s)
      Stone,J.H.,A.Khosroshahi,V.Deshpande,J.H.Umehara
    • Journal Title

      Arthritis & Rheumatism.

      Volume: 64 Pages: 3061-3067

    • Peer Reviewed
  • [Journal Article] Are Classification Criteria for IgG4-RD Now Possible? The Concept of IgG4-Related Disease and Proposal of Comprehensive Diagnostic Criteria in Japan2012

    • Author(s)
      Okazaki, K. and H. Umehara
    • Journal Title

      IntJRheumatol

      Volume: 2012:357071

    • Peer Reviewed
  • [Journal Article] Cutoff Valuesof SerumIg G4 and Histopathological IgG4+ Plasma Cells for Diagnosis of Patients with IgG4-Related Disease.2012

    • Author(s)
      Masaki,Y.,N.Kurose,M.Yamamoto,H.,H.Umehara他.
    • Journal Title

      Int.J.Rheumatol.

    • DOI

      doi:10.1155/2012/580814.

    • Peer Reviewed
  • [Journal Article] Consensus Statementon the Pathology of IgG4-related disease.2012

    • Author(s)
      Deshpande,V.,Y.Zen,J.K.C.Chan,E.Yi,Y.Sato,T.Yoshino,Umehara
    • Journal Title

      Mod.Pathol.

      Volume: 2012(1-12)

    • Peer Reviewed
  • [Journal Article] Proposal for diagnosti ccriteria for IgG4-related kidney disease.2011

    • Author(s)
      KawanoM,SaekiT,NakashimaH,NishiS,YamaguchiY,HisanoS,UmeharaH
    • Journal Title

      Clin Exp Nephrol

      Volume: 15(5) Pages: 615-626

    • Peer Reviewed
  • [Journal Article] IgG4-Related Disease (IgG4+MOLPS)-Diagnostic Criteriaand Diagnostic Problems.2011

    • Author(s)
      MasakiY,IwaoH,NakajimaA,MikiM,SugaiS,UmeharaH.
    • Journal Title

      Current Immunology Reviews

      Volume: 7 Pages: 172-77

    • Peer Reviewed
  • [Presentation] IgG4関連疾患発見の経緯と概念2013

    • Author(s)
      梅原久範
    • Organizer
      第86回日本内分泌学会総会、指定シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2013-04-27
  • [Presentation] IgG4関連疾患包括診断基準2013

    • Author(s)
      梅原久範
    • Organizer
      第57回日本リウマチ学会シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2013-04-20
  • [Presentation] IgG4関連疾患の誕生今、日本から世界にむけて発信!2011

    • Author(s)
      梅原久範
    • Organizer
      第20回日本シェーグレン学会、
    • Place of Presentation
      金沢
    • Year and Date
      2011-09-09
  • [Book] IgG4関連疾患アトラス2012

    • Author(s)
      梅原久範、岡崎和一
    • Total Pages
      199
    • Publisher
      前田書店、金沢

URL: 

Published: 2014-09-25  

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