2012 Fiscal Year Final Research Report
Analysis of glucose intolerance in Ataxia Telangiectasia
| Project/Area Number |
23659517
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TAKAGI Masatoshi 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (10406267)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 小児腫瘍学 / T細胞受容体 / VDJ再構成 / ATM |
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| Research Abstract |
Ataxia Telangiectasia derived cell exhibited defective adipocyte differentiationmachinery. Involvement of transcription factors such as C/EBPα and PPARγisknown to regulate adipocyte differentiation. In this research, we identified micro RNAscontributes adipocyte differentiation, and defective differentiation was results ofmicroRNAs dysregulation by ATM. Especially, over expression on mir-B in ATMdefective cell attenuated adipocyte differentiation.
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