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2012 Fiscal Year Final Research Report

Study on the treatment of highly pathogenic avian influenza H5N1 infections by means of the analysis of pathogenesis of the illness

Research Project

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Project/Area Number 23659523
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionOkayama University

Principal Investigator

MORISHIMA Tsuneo  岡山大学, 大学院・医歯薬学総合研究科, 教授 (90157892)

Co-Investigator(Kenkyū-buntansha) TSUKAHARA Hirokazu  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (90207340)
YAMASHITA Nobuko  岡山大学, 大学院・医歯薬学総合研究科, 助教 (40379798)
Project Period (FY) 2011 – 2012
Keywordsインフルエンザ / 脳症 / 多臓器不全 / 肺炎 / H5N1 / 新型インフルエンザ / サイトカイン
Research Abstract

The pathogenesis of highly pathogenic avian influenza H5N1 in humans has been closelsimilar to those of severe pneumonia and influenza-associated encephalopathy witcytokine storm. Using microarray assay we have analyzed gene expression in the acute phasof 2009pdm infection. Interestingly, gene expression profiles were different betweepneumonia patients and patients with CNS manifestations. Particularly, gene expressiorelated to ROD has been highly activated. Using mouse model, we have shown that thioredoxin-1(TRX) could suppress the oxidativstress and inflammatory changes resulting better outcome in pneumonia with influenzvirus infections. Taking together, anti-oxidant stress agents such as TRX could play an important rolin the severe pneumonia/ARD with H5N1 infections.

  • Research Products

    (7 results)

All 2013 2012

All Journal Article (7 results)

  • [Journal Article] Analysis of bronchoalveolar lavage fluid in a mouse model of bronchial asthma and H1N1 2009 infection2013

    • Author(s)
      Okada S, Hasegawa S, Hasegawa H, Ainai A, Atsuta R, Ikemoto K, Sasaki K, Toda S, Shirabe K, Takahara M, Harada S, Morishima T, Ichiyama T.
    • Journal Title

      Cytokine

      Volume: 63(2) Pages: 194-200

    • DOI

      doi:10.1016/j.cyto.2013.04.035

  • [Journal Article] Pathogenic mechanisms of influenza A(H1N1)pdm09 infection elucidated by gene expression profiling.2013

    • Author(s)
      Yamashita N, Tsukahara H, Tsuge M, Nagaoka Y, Yashiro M, Saito Y, Fujii Y, Takashi O, Morishima T.
    • Journal Title

      Pediatr Int

    • DOI

      doi:10.1111/ped.12139.

  • [Journal Article] Prognostic value of brain injury biomarkers in acute encephalitis/encephalopathy2013

    • Author(s)
      Tsukahara H, Fujii Y, Matsubara K, Yamada M, Nagaoka Y, Saito Y, Yashiro M, Tsuge M, Goto S, Kitamura T, Hata A, Ichiyama T, Morishima T
    • Journal Title

      Pediatr Int.

    • DOI

      doi:10.1111/ped.12094.

  • [Journal Article] Thioredoxin-1 and oxidative stress status in pregnant women at early third trimester of pregnancy: relation to maternal and neonatal characteristics.2013

    • Author(s)
      Nakatsukasa Y, Tsukahara H, Tabuchi K, Tabuchi M, Magami T, Yamada M, Fujii Y, Yashiro M, Tsuge M, Morishima T.
    • Journal Title

      J Clin Biochem Nutr

      Volume: 52(1) Pages: 27-31

    • DOI

      doi:10.3164/jcbn.12-71

  • [Journal Article] Redox-active protein thioredoxin-1 administration ameliorates influenza A virus (H1N1)-induced acute lung injury in mice.2013

    • Author(s)
      Yashiro M, Tsukahara H, Matsukawa A, Yamada M, Fujii Y, Nagaoka Y, Tsuge M, Yamashita N, Ito T, Yamada M, Masutani H, Yodoi J, Morishima T.
    • Journal Title

      Crit Care Med.

      Volume: 41(1) Pages: 171-81

    • DOI

      doi:10.1097/CCM.0b013e3182676352.

  • [Journal Article] Unexpected cardiopulmonary arrest associated with influenza: our experience during the 2009 pandemic in Japan2012

    • Author(s)
      Okumura A, Nakagawa S, Kawashima H, Muguruma T, Saito O, Fujimoto JI, Toida C, Kuga S, Imamura T, Shimizu T, Kondo N, Morishima T.
    • Journal Title

      Influenza Other Respi Viruses.

    • DOI

      doi:10.1111/irv.12032.

  • [Journal Article] National survey of pandemic influenza A (H1N1) 2009-associated encephalopathy in Japanese children.2012

    • Author(s)
      Kawashima H, Morichi S, Okumara A, Nakagawa S, Morishima T.
    • Journal Title

      J Med Virol

      Volume: 84(8) Pages: 1151-6

    • DOI

      doi:10.1002/jmv.23317.

URL: 

Published: 2014-09-25  

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