2013 Fiscal Year Final Research Report
Development of new control methods for Serratia infections using the lytic enzyme of bacteriophage
| Project/Area Number |
23659524
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Kochi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUZAKI Shigenobu 高知大学, 教育研究部医療学系, 准教授 (00190439)
DAIBATA Masanori 高知大学, 教育研究部医療学系, 教授 (50263976)
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| Project Period (FY) |
2011 – 2013
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| Keywords | バクテリオファージ / 溶菌酵素 / ファージ療法 / セラチア菌 / グラム陰性菌 / 外膜 |
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| Research Abstract |
Development of multidrug-resistance makes medical treatment to Serratia marscecens infections by antibiotics difficult. We examined a possible control method to S. marscecens infections using the lytic enzyme of bacteriophage (phage). The complete genome sequences of two Serratia phages KSP90 and KSP100, isolated by us, were analyzed. The genes with lytic enzyme domains, however, were not specified. Alternatively, the lytic enzyme of phage ETA was fused with the possible outer membrane penetration domain of the Bacillus phage lytic enzyme. Examination of bacteriolytic activity of the fused protein to S. marscecens is advanced.
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Research Products
(29 results)
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[Journal Article] Pseudomonas aeruginosa keratitis in mice : effects of topical bacteriophage KPP12 administration2012
Author(s)
Fukuda K, Ishida W, Uchiyama J, Rashel M, Kato S, Morita T, Muraoka A, Sumi T, Matsuzaki S, Daibata M, Fukus hima A
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Journal Title
PLoS One
Volume: 7(10)
Pages: e47742
Peer Reviewed
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