2012 Fiscal Year Final Research Report
Analyses of pathophysiology for molecules causing mental retardation
| Project/Area Number |
23659532
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Institute for Developmental Research, Aichi Human Service Center |
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Principal Investigator |
NAGATA Koh-ichi 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 部長 (50252143)
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| Co-Investigator(Renkei-kenkyūsha) |
INAGUMA Yutaka 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 主任研究員 (10250250)
ITO Hidenori 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 主任研究員 (40311443)
SHINODA Tomoyasu 名古屋大学, 医学部, 助教 (80505652)
NISHIMURA Yoshiaki 同志社大学, 脳科学研究科, 助教 (50508603)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 小児神経学 |
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| Research Abstract |
A2BP1 is implicated in a variety of neurological and developmental disorders. We here prepared a specific antibody against A2BP1 and did protein expression and localization analyses in rodent brain tissues. A2BP1 was expressed in developmental stage-dependent manners in the brain. In cortical neurons, A2BP1 was accumulated mainly in the nucleus and diffusely distributed in the cell body and dendrites. In rat hippocampal neurons, while A2BP1 was found in a punctate distribution adjacent to synapses. Knockdown of A2BP1 caused abnormal neuronal migration during corticogenesis. We did similar analyses as for a polarity-related protein, Lin7, and found the importance of Lin7 in corticogenesis.
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[Journal Article] Cell biological characterization of a multi-domain adaptor protein, ArgBP2, in epithelial NMuMG cells, and identification of a novel short isoform.2012
Author(s)
Murase K, Ito H, Kanoh H, Sudo K, Iwamoto I, Morishita R, Soubeyran P, Seishima M, Nagata K
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Journal Title
Med. Mol. Morphol.
Volume: 45
Pages: 22-28
DOI
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[Journal Article] Phase advance of the light dark cycle perturbs diurnal rhythms of brain derived neurotrophic factor and neurotrophin 3 levels, which reduces synaptophysin positive presynaptic terminals in the cortex of juvenile rats.2011
Author(s)
Hamatake M, Miyazaki N, Sudo K, Matsuda M, Sadakata T, Furuya A, Ichisaka S, Hata Y, Nakagawa C, Nagata K, Furuichi T, Katoh-Semba R
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Journal Title
J. Biol. Chem.
Volume: 286
Pages: 21478-21487
DOI
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[Presentation] SIL1, a causative gene of Marinesco-Sjogren syndrome, plays an essential role inestablishing the architecture of the developing cerebral cortex2012
Author(s)
Nagata K, Inaguma Y, Nishimura YV, Ito H, Suzuki M, Hamada N, Mizuno M, Iwamoto I, Morishita R, Kumagai T.
Organizer
American Society for Cell Biology Annual Meeting
Place of Presentation
San Francisco
Year and Date
20121214-1219
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[Presentation] SIL1, a causative gene of Marinesco-Sjogren syndrome, plays an essential role in establishing the architecture of the developing cerebral cortex.2012
Author(s)
Nagata K, Nishimura YV, Ito H, Taguchi A, Suzuki M, Iwamoto I, Morishita R, Hosokawa M, Kumagai T, Inaguma Y.
Organizer
8th FENS Forum
Place of Presentation
Barcelona, Spain
Year and Date
20120714-0718
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