2011 Fiscal Year Final Research Report
Analysis of human fetal hematopoiesis using human ES cells
| Project/Area Number |
23659533
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OTSU Makoto 東京大学, 医科学研究所, 特任准教授 (30361330)
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| Project Period (FY) |
2011
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| Keywords | ヒトES細胞 / ヒト胎生期造血 / 間葉系幹細胞 / 造血前駆細胞 |
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| Research Abstract |
We established a coculture system of human ES cells with autologous stromal cells derived from human ES cells to induce their differentiation into hematopoietic/blood cells, truly reflecting human fetal hematopoiesis. The human ES cell-derived stromal cells revealed a homologous phenotype of mesenchymal stem cells(MSCs), and hematopoietic/blood cells developed in the coculture with these human ES cell-derived MSCs were shown to originate from adult-type hematopoiesis. The present culture system using autologous human ES cell. derived MSCs can be useful for the analysis of human fetal hematopoiesis.
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