2013 Fiscal Year Final Research Report
Prenatal treatments with bone marrow-derrived stem cells for the fetal diseases
| Project/Area Number |
23659537
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | National Research Institute for Child Health and Development |
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Principal Investigator |
HAYASHI Satoshi 独立行政法人国立成育医療研究センター, その他部局等, その他 (60425717)
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| Co-Investigator(Kenkyū-buntansha) |
UMEZAWA Akihiro 独立行政法人国立成育医療研究センター, 生殖・細胞医療研究部, 部長 (70213486)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 胎児医学 / 免疫寛容 / 細胞移植 / 前臨床研究 |
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| Research Abstract |
In this study, we focused on a novel therapeutic approach to genetic diseases. We investigated the donor cell chimerism by implantation of hematopoietic stem cells in the disease model mice, and evaluated therapeutic effect by survival of donor cells after transplantation of bone marrow cells. We show availability of cell-based therapy on the disease model animal by demonstrating acquisition of immune tolerance.
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