2011 Fiscal Year Final Research Report
Production of a novel diagnostic tool for bullous pemphigoid using cleavage site-specific antibodies.
| Project/Area Number |
23659538
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Hokkaido University |
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Principal Investigator |
NISHIE Wataru 北海道大学, 北海道大学病院, 講師 (20443955)
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| Project Period (FY) |
2011
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| Keywords | 皮膚診断学 |
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| Research Abstract |
Bullous pemphigoid(BP) is an autoimmune blistering disease. The aim of this study is to clarify the pathogenesis of BP, which may be useful for early and accurate diagnosis. To address this, we aimed at the finding that blister fluid of BP patients can cleave the collagen XVII(COL17) which is an autoantigen for BP. We have established a method to obtain highly purified recombinant COL17, which was actually cleaved by blister fluid from BP patients within the juxtamembranous NC16A domain.
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