2013 Fiscal Year Final Research Report
A study to establish system to evaluate diversities of cell populations of melanoma
| Project/Area Number |
23659543
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Chiba University |
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Principal Investigator |
HIROYUKI Matsue 千葉大学, 医学(系)研究科(研究院), 教授 (10250424)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMATA Noriaki 千葉大学, 医学部附属病院, 講師 (00334186)
TOGAWA Yaei 千葉大学, 大学院医学研究院, 助教 (90361427)
OHARA Osamu (財)かずさDNA 研究所, ヒトゲノム研究部, 部長 (20370926)
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| Project Period (FY) |
2011 – 2012
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| Keywords | がん / 悪性黒色腫 / がん幹細胞 |
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| Research Abstract |
Cancer is not a group composed of tumor cells derived from a single malignant cell, but a group of the cells possessing accumulated genetic diversities derived from a cancer stem cell. To eradicate cancer, all malignant cells forming cancer must become therapeutic targets. The purpose of this proposed pilot feasibility study was ultimately to establish a reliable method to analyze genetic diversities of malignant melanoma using next-generation sequencing. The first step was to evaluate individual differences and reproducibility of the method from the results of skin-derived cells.
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[Journal Article] Therapeutic potential of B and T lymphocyte attenuator expressed on CD8+ T cells for contact hypersensitivity2013
Author(s)
Nakagomi D, Suzuki K, Hosokawa J, Kobayashi Y, Suto A, Takatori H, Watanabe N, Matsue H, Murphy TL, Murphy KM, Shimada S, Nakajima H
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Journal Title
J Invest Dermatol
Volume: 133(3)
Pages: 702-11
DOI
Peer Reviewed
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