2011 Fiscal Year Final Research Report
Identification of marker molecules specific for regulatory B cells
| Project/Area Number |
23659544
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2011
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| Keywords | 皮膚免疫 / B細胞 / 転写因子 |
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| Research Abstract |
Recently, the important roles of"regulatory B cells"in the regulation of immune responses have been widely appreciated. To further clarify the molecular mechanisms of regulatory B cell functions, identification of marker molecules specific for regulatory B cells is necessary. In this study, we have attempted to identify such genes using comprehensive gene expression analysis. We have identified approximately 180 candidate genes. We are currently studying the in vivo and in vitro functions of 10 candidate transcriptional genes among them.
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