2011 Fiscal Year Final Research Report
Molecular Mechanism of Chemotherapy Resistance of Malignant Melanoma
| Project/Area Number |
23659548
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Nagoya University |
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Principal Investigator |
OGAWA Yasushi 名古屋大学, 医学部附属病院, 病院助教 (10567754)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 皮膚病理学 / ケミカルバイオロジー |
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| Research Abstract |
The role of the protein kinase DYRK1B on chemoresistant G0 quiescent malignant melanoma cellswas investigated. DYRK1B is enriched in G0 phase cells and shows enhanced expression in several chemoresistant carcinoma cell lines including malignant melanoma-derived cell lines. Histopathology confirmed that a population of cells have elevated expression of DYRK1B in malignant melanoma specimens. DYRK1B specific kinase inhibitor sensitized chemoresistant carcinoma cell lines to conventional anti-cancer drugs. Attempt to establish an in vivoquiescent cell imaging system has been so far unsuccessful.
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