• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2012 Fiscal Year Final Research Report

Molecular mechanism of urticarial development

Research Project

  • PDF
Project/Area Number 23659550
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

HIRAKAWA Satoshi  浜松医科大学, 医学部, 准教授 (50419511)

Project Period (FY) 2011 – 2012
Keywords血管内皮細胞 / 細胞間接着 / シェディング / ヒスタミン / マイクロ流路
Research Abstract

The biochemical cleavage of VE-cadherin was found in cultured endothelial cells. Western blot analysis from cell lysates and conditioned media revealed that VE-cadherin undergoes ectodomain shedding in response to histamine, leading to the disruption of EC junctions and the induction of vascular hyperpermeability. These findings represent the development of urticaria, a pathological alteration of vasculature in the skin.

  • Research Products

    (23 results)

All 2013 2012 2011 2010 Other

All Journal Article (10 results) Presentation (9 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Topical simvastatin accelerates wound healing in diabetes by enhancing angiogenesis and lymphangiogenesis2012

    • Author(s)
      Asai J, Takenaka H, Hirakawa S, Sakabe J, Hagura A, Kishimoto S, Maruyama K, Kajiya K, Kinoshita S, Tokura Y , Katoh N.
    • Journal Title

      Am J Pathol

      Volume: 181 Pages: 2217-24

  • [Journal Article] Induced lymphatic sinus hyperplasia in sentinel lymph nodes by VEGF-C as the earliest premetastatic indicator2012

    • Author(s)
      Liersch R, Hirakawa S, Berdel WE, Mesters RM, Detmar M
    • Journal Title

      Int J Oncol

      Volume: 41 Pages: 2073-8

  • [Journal Article] A palmtop-sized microfluidic cell culture system driven by a miniaturized infusion pump2012

    • Author(s)
      Sasaki N, Shinjo M, Hirakawa S, Nishinaka M, Tanaka Y, Mawatari K, Kitamori T, Sato K
    • Journal Title

      Electrophoresis

      Volume: 33 Pages: 1729-1735

  • [Journal Article] Targeted overexpression of Angptl6/angiopoietin-related growth factor in the skin promotes angiogenesis and lymphatic vessel enlargement in response to ultraviolet B2012

    • Author(s)
      Okazaki H, Hirakawa S, Shudou M, Nakaoka Y, Shirakata Y, Miyata K, Oike Y,Hashimoto K, Sayama K.
    • Journal Title

      J Dermatol

      Volume: 39 Pages: 366-74

  • [Journal Article] Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis2011

    • Author(s)
      Aoi J, Endo M, Kadomatsu T, Miyata K, Nakano M, Horiguchi H, Ogata A, Odagiri H, Yano M, Araki K, Jinnin M, Ito T , Hirakawa S, Ihn H, Oike Y
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 7502-12

  • [Journal Article] Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse2011

    • Author(s)
      Kerjaschki D, Bago-Horvath Z, Rudas M, Sexl V, Schneckenleithner C, Wolbank S, Bartel G, Krieger S, Kalt R, Hantusch B, Keller T, Nagy-Bojarszky K, Huttary N, Raab I, Lackner K, Krautgasser K, Schachner H, Kaserer K, Rezar S, Madlener S, Vonach C, Davidovits A, Nosaka H, Hammerle M, Viola K, Dolznig H, Schreiber M, Nader A, Mikulits W, Gnant M, Hirakawa S, Detmar M, Alitalo K, Nijman S, Offner F, Maier TJ, Steinhilber D, Krupitza G
    • Journal Title

      J Clin Invest

      Volume: 121 Pages: 2000-12

  • [Journal Article] Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes2011

    • Author(s)
      Dai X, Sayama K, Tohyama M, Shirakata Y, Hanakawa Y, Tokumaru S, Yang L, Hirakawa S, Hashimoto K
    • Journal Title

      J Allergy Clin Immunol

      Volume: 127 Pages: 806-14

  • [Journal Article] PPARγ mediates innate immunity by regulating the 1α,25-dihydroxyvitamin D3 induced hBD-3 and cathelicidin in human keratinocytes2010

    • Author(s)
      Dai X, Sayama K, Tohyama M, Shirakata Y, Hanakawa Y, Tokumaru S, Yang L, Hirakawa S, Hashimoto K
    • Journal Title

      J Dermatol Sci

      Volume: 60 Pages: 179-86

  • [Journal Article] E2 polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity.2010

    • Author(s)
      Sayama K, Yamamoto M, Shirakata Y, Hanakawa Y, Hirakawa S, Dai X, Tohyama M, Tokumaru S, Shin MS, Sakurai H, Akira S, Hashimoto K
    • Journal Title

      J Biol Chem

      Volume: 39 Pages: 30042-9

  • [Journal Article] Inflammatory mediator TAK1 regulates hair follicle morphogenesis and anagen induction shown by using keratinocyte-specific TAK1-deficient mice2010

    • Author(s)
      Sayama K, Kajiya K, Sugawara K, Sato S, Hirakawa S, Shirakata Y, Hanakawa Y, Dai X, Ishimatsu-Tsuji Y, Metzger D, Chambon P, Akira S, Paus R, Kishimoto J, Hashimoto K
    • Journal Title

      PLoS ONE

      Volume: 5 Pages: e11275-84

  • [Presentation] 皮膚と循環:血管・リンパ管から考える病態生理2013

    • Author(s)
      平川 聡史
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      20130327-0329
  • [Presentation] 皮膚と循環:血管・リンパ管から考える病態生理. シンポジウム:階層的循環システム構築の機序とその破綻2013

    • Author(s)
      平川 聡史
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-28
  • [Presentation] A functional role of LYVE-1 in VEGF-A-induced lymphangiogenesis and psoriasis2012

    • Author(s)
      Hirakawa S.
    • Organizer
      The 61st annual Montania Symposium
    • Place of Presentation
      Gleneden Beach, Oregon
    • Year and Date
      20121011-1015
  • [Presentation] Elevated expression of LYVE-1 in novel three-dimensional constructs by cultured dermal lymphatic endothelial cells.2011

    • Author(s)
      Hirakawa S, Kadowaki K, Matsusaki M, Akashi M, Tokura Y
    • Organizer
      The 36th annual meeting of the Society for Japanese Investigative Dermatology
    • Place of Presentation
      Kyoto
    • Year and Date
      20111209-1210
  • [Presentation] Pathological lymphangiogenesis requires VEGF-A for endothelial proliferation and migration.2011

    • Author(s)
      Hirakawa S
    • Organizer
      The 9th Japan-Korea Joint Symposium on Vascular Biology
    • Place of Presentation
      Busan, South Korea
    • Year and Date
      20110825-0826
  • [Presentation] Lymphatic vessels in inflammation and tumor metastasis2011

    • Author(s)
      Hirakawa S
    • Organizer
      8th International Symposium on the Biology of Endothelial cell
    • Place of Presentation
      Zurich, Switzerland
    • Year and Date
      20110615-0618
  • [Presentation] リンパ管新生とリンパ節転移の基礎的解析2011

    • Author(s)
      平川 聡史
    • Organizer
      第35回日本リンパ学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-04
  • [Presentation] Pathological angiogenesis and lymphangiogenesis.2011

    • Author(s)
      Hirakawa S
    • Organizer
      World Congress of Dermatology 2011
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2011-05-24
  • [Presentation] 癌とリンパ管新生2011

    • Author(s)
      平川 聡史
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-28
  • [Book] 慢性炎症におけるリンパ管新生2012

    • Author(s)
      平川 聡史
    • Total Pages
      280-286
    • Publisher
      佐藤靖史(編集) 医薬ジャーナル社
  • [Book] がん転移とリンパ管ニッチ

    • Author(s)
      平川 聡史
    • Total Pages
      167-172
    • Publisher
      須田年生(編集) 羊土社
  • [Remarks]

    • URL

      http://www2.hama-med.ac.jp/w1b/derm/achievements/index.html

  • [Patent(Industrial Property Rights)] 血管透過性亢進抑制作用の評価法2013

    • Inventor(s)
      山内 豊彦、平川聡史、山下 豊、戸倉 新樹
    • Industrial Property Rights Holder
      国立大学法人浜松医科大学・浜松ホトニクス株式会社
    • Industrial Property Number
      特願 2013-034570
    • Filing Date
      2013-02-25
    • Overseas

URL: 

Published: 2014-09-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi