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2012 Fiscal Year Final Research Report

Development of the visualization method of the stratum corneum barrier function by Time-of-Flight Secondary Ion Mass Spectroscopy (TOF-SIMS)

Research Project

  • PDF
Project/Area Number 23659555
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionKeio University

Principal Investigator

KUBO Akiharu  慶應義塾大学, 医学部, 講師 (70335256)

Project Period (FY) 2011 – 2012
Keywords皮膚病退学 / 皮膚生理・生物学 / イメージング / 皮膚バリア / アトピー性皮膚炎
Research Abstract

The stratum corneum (SC), the outermost barrier of mammalian bodies, consists of layers of cornified keratinocytes with intercellular spaces sealed with lipids. The insolubility of the SC has hampered in-depth analysis, and the SC has been considered a ho

  • Research Products

    (6 results)

All 2013 2012 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results) Remarks (2 results)

  • [Journal Article] The stratum corneum comprises three layers with distinct metal-ion barrier properties2013

    • Author(s)
      Kubo A, Ishizaki I, Kubo A, Kawasaki H, Nagao K, Ohashi Y, and Amagai M
    • Journal Title

      Sci Rep

      Volume: 3 Pages: 1731

    • Peer Reviewed
  • [Presentation] 3D Imaging of the Mammalian Epidermis2012

    • Author(s)
      Kubo A
    • Organizer
      37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Okinawa, Japan
    • Year and Date
      20121207-08
  • [Presentation] The stratum corneum comprises three layers with distinct barrier properties, as revealed by TOF-SIMS imaging.2012

    • Author(s)
      Kubo A, Ishizaki I, Kubo A, Kawasaki H, Ohashi Y, and Amagai M
    • Organizer
      62nd Montagna Symposium on the Biology of Skin 2012
    • Place of Presentation
      Portland, Oregon,USA
    • Year and Date
      20121011-13
  • [Presentation] High-resolution TOF-SIMS Imaging reveals Multi-layered Barrier Structure of the Stratum Corneum of Skin.2012

    • Author(s)
      Kubo A, Ishizaki I, Kubo A, Kawasaki H, Ohashi Y, and Amagai M
    • Organizer
      19th International Mass Spectrometry Conference
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      20120916-17
  • [Remarks] 皮膚バリア機構解明プロジェクト

    • URL

      http://www.derma.med.keio.ac.jp/derma/r_research/project7.html

  • [Remarks] 皮膚"バリオロジー":バリア機能異常から見たアレルギー疾患病態解明

    • URL

      http://www.careerpath-prj.keio.ac.jp/kanrinmaru/scholar/kubo/index.html

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Published: 2014-08-29   Modified: 2014-10-07  

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