2012 Fiscal Year Final Research Report
Study of synthesis and metabolism of D-serine in the brain
| Project/Area Number |
23659557
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Chiba University |
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Principal Investigator |
HASHIMOTO Kenji 千葉大学, 社会精神保健教育研究センター, 教授 (10189483)
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| Co-Investigator(Renkei-kenkyūsha) |
IYO Masaomi 千葉大学, 大学院・医学研究院, 教授 (50191903)
MORI Hisashi 富山大学, 大学院・医学薬学研究部(医学), 教授 (00239617)
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| Project Period (FY) |
2011 – 2012
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| Keywords | D 型アミノ酸 / D 型セリン / D 型アスパラギン酸 / セリンラセマーゼ |
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| Research Abstract |
D-serine in the brain is known to be synthesized from serine racemase (SRR). In this study, we found that levels of D-aspartic acid I the forebrain of SRR knock-out (KO) mice was significantly lower than those of wild type mice. Furthermore, the enzymatic activity of D-aspartate oxidase (DDO) in the forebrain of SRR-KO mice was not changed. It is unlikely that DDO activity plays a role in the findings of this study.
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[Journal Article] (2013) Decreased levels of D-aspartic acid in the forebrain of serine racemase (Srr) knock-out mice.2013
Author(s)
Horio, M., Ishima, T., Fujita, Y., Inoue, R., Mori, H., and Hashimoto, K.
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Journal Title
Neurochem. Int.
Volume: 62
Pages: 843-847
DOI
Peer Reviewed
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[Journal Article] (2011) Levels of D-serine in the brain and peripheral organs of serine racemase (Srr) knock-out mice.2011
Author(s)
Horio, M., Kohno, M., Fujita, Y., Ishima, T., Inoue, R., Mori, H., and Hashimoto, K.
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Journal Title
Neurochem. Int.
Volume: 59
Pages: 853-859
DOI
Peer Reviewed
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