2011 Fiscal Year Final Research Report
Mood episode-dependent metabolome analysis of bipolar disorder model mice
| Project/Area Number |
23659569
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KASAHARA Takaoki 独立行政法人理化学研究所, 精神疾患動態研究チーム, 副チームリーダー (50344031)
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| Project Period (FY) |
2011
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| Keywords | 双極性障害 / モデルマウス / ミトコンドリアDNA / メタボローム解析 / 血漿 / Hydroxyprogesterone |
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| Research Abstract |
We performed metabolome analysis using bipolar disorder model mice, which we have developed, to elucidate the physiological change at the molecular level during hypoactivity episodes the model showed. Plasma concentration of molecules related to cellular energy metabolism and cholesterol metabolism were significantly altered. Because these metabolites are to be in human plasma, the present result will lead to future clinical studies.
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