2012 Fiscal Year Final Research Report
Early andspecific detection of unstable atherosclerotic pl:aqTuiesssue factor imaging using pre-targeting systems
| Project/Area Number |
23659573
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
KUGE Yuji 北海道大学, アイソトープ総合センター, 教授 (70321958)
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| Co-Investigator(Kenkyū-buntansha) |
ZHAO Songji 北海道大学, 大学院・医学研究科, 教授 (80374239)
NISHIJIMA Ken-ichi 北海道大学, 大学院・医学研究科, 特任講師 (60364254)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAI Keiichi 金沢大学, 保健学系, 教授 (30204663)
YAMASHITA Atsushi 宮崎大学, 医学部, 助教 (90372797)
NISHIJIMA Ken-ichi 北海道大学, 大学院・医学研究科, 特任講師 (60364254)
SHIMIZU Youichi 北海道大学, アイソトープ総合センター, 助教 (90634212)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 放射線 / 核医学診断 / 動脈硬化 / 不安定プラーク / 組織因子 |
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| Research Abstract |
We performed several experiments to establish a new nuclear medicine technique for imaging unstable atherosclerotic plaques through specific detection of tissue factor (TF). Consequently, we obtained several new findings concerning: 1) synthesis methods of 18F-laveled biotin-derivative, 2) PET imaging protocols and TF expression levels in our rabbit model, 3) accumulation of anti-rabbit TF monoclonal antibody in atherosclerotic lesions, and 4) blood clearance of anti-rabbit TF monoclonal antibody. These findings provided important information to establish a new nuclear medicine technique for TF imaging.
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Research Products
(4 results)
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[Journal Article] Arterial 18F-fluorodeoxyglucose uptake reflects thrombus formation and tissue factor expression via nuclear factor-κB in rabbit atherosclerotic lesions
Author(s)
Atsushi Yamashita, Yan Zhao, Songji Zhao, Yunosuke Matsuura, Chihiro Sugita, Takashi Iwakiri, Nozomi Okuyama, Kazuyo Ohe, Chihiro Koshimoto, Keiichi Kawai, Nagara Tamaki, Yuji Kuge, and Yujiro Asada
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Journal Title
Circulation Journal
Volume: (In press)
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[Presentation] 18F-fluorodeoxyglucose uptake reflects thrombus formation and tissue factor expression via nuclear factor-kB in rabbit atherosclerotic lesions2012
Author(s)
Atsushi Yamashita, Yan Zhao, Yunosuke Matsuura, Kazuaki Yamasaki Chihiro Sugita, Keiichi Kawai, Nagara Tamaki, Songji Zhao, Yuji Kuge, Yujiro Asada
Organizer
American Heart Association Scientific Sessions 2012
Place of Presentation
Los Angeles Convention Center, Los Angeles, CA, U.S.A
Year and Date
20121103-07
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