2012 Fiscal Year Final Research Report
A new tracer development for positron emission tomographic imaging with an isotope62Zn containing porphyrins
| Project/Area Number |
23659576
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANEKO Tsuyoshi 筑波大学, 医学医療系, 講師 (90510181)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 放射線腫瘍学 |
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| Research Abstract |
To develop a new tracer for positron emission tomography imaging(PET), we newly synthesized 62Zn containing porphyrin derivatives which have been reported to be accumulated in neoplastic cells. We investigated the efficacy of our Zn-porphyrins for tumor-area diagnosis with cancer cell-transplanted mice. These tracers were accumulated in the tumor tissue, as well as the liver and the spleen: both organs play important role for heme metabolisms. According to these results, 62Zn-porphyrin is suggested to be one of candidates for a tumor tracer in PET imaging.
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[Journal Article] Cancer cells uptake porphyrins via heme carrier protein 12012
Author(s)
Kazuhiro Hiyama, Hirofumi Matsui, Masato Tamura, Osamu Shimokawa, Mariko Hiyama, Tsuyoshi Kaneko, Yumiko Nagano, Ichinosuke Hyodo, Junko Tanaka, Yoshihiro Miwa, Tetsuo Ogawa, Takeo Nakanishi and Ikumi Tamai
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Journal Title
Journal of Porphyrins and Phthalocyanines
Volume: 16
Pages: 1-8
Peer Reviewed
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[Journal Article] Identification of a unique nsaid, fluoro-loxoprofen with gastroprotective activity2012
Author(s)
Suemasu S, Yamakawa N, Ishihara T, Asano T, Tahara K, Tanaka K, Matsui H, Okamoto Y, Otsuka M, Takeuchi K, Suzuki H, Mizushima T
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Journal Title
Biochem Pharmacol
Volume: 84(11)
Pages: 1470-81
Peer Reviewed
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[Journal Article] Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line2012
Author(s)
Indo HP, Inanami O, Koumura T, Suenaga S, Hsiu-Chuan Yen, Kakinuma S, Matsumoto K, Nakanishi I, St Clair W, St Clair DK, Matsui H, Cornette R, Gusev O, Okuda T, Nakagawa Y, Ozawa T and Majima HJ
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Journal Title
HLE, Free radical research
Volume: 46(8)
Pages: 1029-1043
Peer Reviewed
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