2012 Fiscal Year Final Research Report
Development of a novel chelating agent suitable for the prelabeling to establish a generic method for preparation of radiolabeled antibodies.
| Project/Area Number |
23659578
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Mitsuaki 近畿大学, 農学部, 講師 (20433641)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 抗体 / 放射性同位元素 / 有機化学 |
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| Research Abstract |
We planned to develop a novel chelating agent suitable for the prelabeling to establish a generic method for preparation radiolabeled antibodies. CHX-DTPA was selected as a chelate group, and then CHX-DTPA-Bn-Gly, which conjugated Gly via benzene ring attached to backbone carbon, was designed and synthesized. The chelating agent could be radiolabeled with indium-111 at low concentration, and it showed rapid urinary excretion. These results indicated that CHX-DTPA-Bn-Gly is a promising mother compound of the novel chelating agent.
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