ＭＲＩによる軟骨評価ソフトウェアを用いた変形性股関節症関連因子の解明

2013 Fiscal Year Annual Research Report

• Project/Area Number: 23659580
• Research Institution: The University of Tokyo
• Principal Investigator: 村木 重之 東京大学, 医学部附属病院, 助教 (40401070)
• Co-Investigator(Kenkyū-buntansha): 吉村 典子 東京大学, 医学部附属病院, 准教授 (60240355) ; 阿久根 徹 東京大学, 医学部附属病院, 准教授 (60282662) ; 岡 敬之 東京大学, 医学部附属病院, 助教 (60401064)
• Keywords: 医療・福祉 / 老化 / MRI / 疫学 / 変形性関節症 / 関節リウマチ

Research Abstract

本年度は、昨年度Validationが終了したMRIによる股関節軟骨の軟骨定量評価用解析ソフトウエアおよび軟骨質的評価用解析ソフトウエアを実臨床に導入し、軟骨変化の意義に関して検討を行った。
Xpによる評価にて、一方の股関節のみ変化が生じている（Larsen３以上）関節リウマチ患者20例で運動量に影響を受けづらい遅延相軟骨造影MRI(delayed gadolinium-enhanced magnetic resonance imaging for cartilage：dGEMRIC）の撮像を行い、軟骨質的評価用解析ソフトウエアを用いた解析を施行した。MRIは3D条件で撮像を行っており、同ソフトウエア内で前額断での再構築を行い、荷重部位と非荷重部位にクラスタリングした後に、内部のpixcelのMRI値を記録したxmlファイルを集計した。
dGEMRICでは T1 valueが低い際に軟骨破壊が示唆されており、800より上の場合十分なcontent of GAGだと判定する。解析の結果、非荷重部位で正常群と疾患群で差は認められなかったが、荷重部位では正常群のT1値平均は1011、疾患群のT1値平均は730(p<0.0001)と有意差を認めた。上述した結果は、Xpにて変化がある荷重部位の軟骨変化を、3次元的に抽出して定量的に求めることが可能になったことを意味している。
我々が開発した「股関節軟骨の軟骨定量評価用解析ソフトウエアおよび軟骨質的評価用解析ソフトウエア」が完成するまでは、実臨床において多彩な疾患に対応可能な撮像法を検討することさえ出来なかったが、本年度は開発したソフトウエアの実臨床における運用に成功し、今後の大規模データへのシステムの適用の見通しも立った。

Research Products

• [Journal Article] Association of Dietary Intake with Joint Space Narrowing and Osteophytosis at the Knee in Japanese Men and Women: The ROAD Study (2014)
  • Author(s): Muraki S, Akune T, En-yo Y, Yoshida M, Tanaka S, Kawaguchi H, Nakamura K, Oka H, Yoshimura N.
  • Journal Title: Modern Rheum Volume: in press Pages: in press
  • Peer Reviewed
• [Journal Article] Prevalence, Incidence, and Progression of Lumbar Spondylosis by Gender and Age Strata (2014)
  • Author(s): Muraki S, Yoshimura N, Akune T, Sakae Tanaka, Ikuno Takahashi, Saeko Fujiwara.
  • Journal Title: Modern Rheum Volume: in press Pages: in press
  • Peer Reviewed
• [Journal Article] Prevalence and progression of radiographic ossification of the posterior longitudinal ligament and associated factors in the Japanese population: A 3-year follow-up of the ROAD study (2014)
  • Author(s): Yoshimura N, Nagata K, Muraki S, Oka H, Yoshida M, Enyo Y, Kagotani R, Hashizume H, Yamada H, Ishimoto Y, Teraguchi M, Tanaka S, Kawaguchi H, Toyama Y, Nakamura K, Akune T.
  • Journal Title: Osteoporos Int Volume: 25 Pages: 1089-98
  • DOI: doi: 10.1007/s00198-013-2489-0.
  • Peer Reviewed
• [Journal Article] Incidence of certified need of care in the long-term care insurance system and its risk factors in the elderly of Japanese population-based cohorts: The ROAD study. (2014)
  • Author(s): Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Tokimura F, Yoshida H, Suzuki T, Nakamura K, Yoshimura N.
  • Journal Title: Geriatr Gerontol Int Volume: in press Pages: in press
  • DOI: doi: 10.1111/ggi.12155.
  • Peer Reviewed
• [Journal Article] Prevalence of knee pain, lumbar pain and its co-existence in Japanese men and women: The LOCOMO (Longitudinal Cohorts of Motor System Organ) study. (2014)
  • Author(s): Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Omori G, Sudo A, Nishiwaki Y, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K.
  • Journal Title: J Bone Miner Metab. Volume: in press Pages: in press
  • Peer Reviewed
• [Journal Article] Exercise habits during middle age are associated with lower prevalence of sarcopenia: the ROAD study. (2014)
  • Author(s): Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • Journal Title: Osteoporos Int Volume: 25 Pages: 1081-8
  • DOI: doi: 10.1007/s00198-013-2550-z.
  • Peer Reviewed
• [Journal Article] Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: The Wakayama Spine Study (2014)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Minamide A, Oka H, Ishimoto Y, Nagata K, Kagotani R, Takiguchi N, Akune T, Kawaguchi H, Nakamura K, Yoshida M.
  • Journal Title: Osteoarthritis Cartilage Volume: 22 Pages: 104-10
  • DOI: doi: 10.1016/j.joca.2013.10.019.
  • Peer Reviewed
• [Journal Article] Association of knee osteoarthritis with onset and resolution of pain and physical functional disability: The ROAD Study (2014)
  • Author(s): Muraki S, Akune T, Nagata K, Ishimoto Y, Yoshida M, Tokimura F, Tanaka S, Oka H, Kawaguchi H, Nakamura K, Yoshimura N.
  • Journal Title: Modern Rheum Volume: in press Pages: in press
  • Peer Reviewed
• [Journal Article] Association of physical activities of daily living with the incidence of certified need of care in the long-term care insurance system of Japan: the ROAD study. (2014)
  • Author(s): Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Tokimura F, Yoshida H, Suzuki T, Nakamura K, Yoshimura N
  • Journal Title: J Orthop Sci Volume: in press Pages: in press
  • Peer Reviewed
• [Journal Article] Incidence of disability and its associated factors in Japanese men and women: The Longitudinal Cohorts of Motor System Organ (LOCOMO) study (2014)
  • Author(s): Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Nishiwaki Y, Sudo A, Omori G, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K.
  • Journal Title: J Bone Miner Metab. Volume: in press Pages: in press
  • Peer Reviewed
• [Journal Article] Prevalence of diffuse idiopathic skeletal hyperostosis of the whole spine and its association with knee osteoarthritis: the ROAD study. (2014)
  • Author(s): Kagotani R, Yoshida M, Muraki S, Oka H, Hashizume H, Yamada H, Enyo Y, Nagata1 K, Ishimoto Y, Teraguchi M, Tanaka S, Nakamura K, Kawaguchi H, Akune T, Yoshimura N.
  • Journal Title: J Bone Miner Metab. Volume: in press Pages: in press
  • Peer Reviewed
• [Journal Article] The prevalence of cervical myelopathy among subjects with narrow cervical spinal canal in a population-based MRI study: The Wakayama Spine Study. (2014)
  • Author(s): Nagata K, Yoshimura N, Hashizume H, Muraki S, Ishimoto Y, Yamada H, Takiguchi N, Nakagawa Y, Minamide A, Oka H, Kawaguchi H, Nakamura K, Akune T, Yoshida M
  • Journal Title: Spine J Volume: in press Pages: in press
  • DOI: doi: 10.1016/j.spinee.2014.03.051.
  • Peer Reviewed
• [Journal Article] Physical Performance, Bone and Joint Diseases, and Incidence of Falls in Japanese Men and Women: A Longitudinal Cohort Study. (2013)
  • Author(s): Muraki S, Akune T, Oka H, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Nakamura K, Kawaguchi H, Yoshimura N.
  • Journal Title: Osteoporos Int Volume: 24 Pages: 459-466
  • DOI: doi: 10.1007/s00198-012-1967-0.
  • Peer Reviewed
• [Journal Article] Risk factors for falls in a longitudinal population-based cohort study of Japanese men and women: The ROAD Study (2013)
  • Author(s): Muraki S, Akune T, Ishimoto Y, Nagata K, Yoshida M, Tanaka S, Oka H, Kawaguchi H, Nakamura K, Yoshimura N.
  • Journal Title: Bone Volume: 52 Pages: 516-23
  • DOI: doi: 10.1016/j.bone.2012.10.020.
  • Peer Reviewed
• [Journal Article] The mid-term efficacy of intra-articular hyaluronic acid injections on joint structure: A nested case-control study. (2013)
  • Author(s): Oka H, Akune T, Muraki S, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N.
  • Journal Title: Modern Rheum Volume: 23 Pages: 722-8
  • DOI: doi: 10.1007/s10165-012-0725-7.
  • Peer Reviewed
• [Journal Article] Associations between radiographic lumbar spinal stenosis and clinical symptoms in the general population: The Wakayama Spine Study (2013)
  • Author(s): Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, Takiguchi N, Minamide A, Oka H, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
  • Journal Title: Osteoarthritis Cartilage Volume: 21 Pages: 783-8
  • DOI: doi: 10.1016/j.joca.2013.02.656.
  • Peer Reviewed
• [Journal Article] Profiles of vitamin D insufficiency and deficiency in Japanese men and women: Association with biological, environmental, and nutritional factors and coexisting disorders: The ROAD study (2013)
  • Author(s): Yoshimura N, Muraki S, Oka H, Morita M, Yamada H, Tanaka S, Kawaguchi H, Nakamura K, Akune T.
  • Journal Title: Osteoporos Int Volume: 24 Pages: 2775-87
  • DOI: doi: 10.1007/s00198-013-2372-z.
  • Peer Reviewed
• [Presentation] 変形性膝関節症の定量評価：The ROAD Study (2014)
  • Author(s): 38. 村木重之
  • Organizer: 膝OAと運動・装具療法セミナー
  • Place of Presentation: 福岡（ホテルオークラ福岡）
  • Year and Date: 20140131-20140131
  • Invited
• [Presentation] Prevalence of sarcopenia and its association with exercise habits in middle age and physical performance in the elderly participants of Japanese population-based cohorts: the ROAD study (2013)
  • Author(s): Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura, K, Oka H, Yoshimura N
  • Organizer: IOF regionals
  • Place of Presentation: Hong Kong, China
  • Year and Date: 20131212-20131215
• [Presentation] 変形性股関節症の有病率および股関節痛との関連 ―The ROAD Studyー (2013)
  • Author(s): 村木重之
  • Organizer: 日本股関節学会
  • Place of Presentation: 広島（広島国際会議場）
  • Year and Date: 20131129-20131130
  • Invited
• [Presentation] 大規模縦断研究による変形性膝関節症の疫学 (2013)
  • Author(s): 村木重之
  • Organizer: 膝OAと運動・装具療法セミナー
  • Place of Presentation: 神戸（神戸国際会議場）
  • Year and Date: 20130705-20130705
  • Invited
• [Presentation] Risk Factors for Multiple Falls in Japanese Men and Women: The ROAD Study. (2013)
  • Author(s): Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura, K, Oka H, Yoshimura N
  • Organizer: 2nd Joint Meeting of the International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR)
  • Place of Presentation: Kobe, Japan
  • Year and Date: 20130528-20130601
• [Presentation] Higher levels of serum 25(OH)D prevents the occurrence of osteoporosis, but deteriorates knee osteoarthritis: The ROAD study (2013)
  • Author(s): Yoshimura N, Muraki S, Oka H, Nakamura K, Tanaka S, Kawaguchi H, Akune T
  • Organizer: IOF
  • Place of Presentation: Rome, Italy
  • Year and Date: 20130417-20130421
• [Presentation] The Incidence Rate and Risk Factors for Radiographic Knee Osteoarthritis and Knee Pain: The ROAD Study (2013)
  • Author(s): Muraki S, Akune T, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • Organizer: IOF
  • Place of Presentation: Rome, Italy
  • Year and Date: 20130417-20130421
• [Presentation] Association of diffuse idiopathic skeletal hyperostosis and bone mineral density and marker of bone metabolism: the ROAD study (2013)
  • Author(s): Kagotani R, Muraki S, Oka H, Yoshida M, Hashizume H, Yamada H, Nagata K, Ishimoto Y, Teraguchi M, Tanaka S, Nakamura K, Kawaguchi H, Akune T, Yoshimura N.
  • Organizer: IOF
  • Place of Presentation: Rome, Italy
  • Year and Date: 20130417-20130421