Factors associated with hip osteoarthritis using MRI

2013 Fiscal Year Final Research Report

• Project/Area Number: 23659580
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: The University of Tokyo
• Principal Investigator: MURAKI Shigeyuki 東京大学, 医学部附属病院, 助教 (40401070)
• Co-Investigator(Kenkyū-buntansha): YOSHIMURA Noriko 東京大学, 医学部附属病院, 特任准教授 (60240355) ; AKUNE Toru 東京大学, 医学部附属病院, 特任准教授 (60282662) ; OKA Hiroyuki 東京大学, 医学部附属病院, 特任助教 (60401064)
• Project Period (FY): 2011 – 2013
• Keywords: 医療・福祉 / 老化 / MRI / 疫学 / 変形性関節症 / 関節リウマチ

Research Abstract

In the present study, we developed a hip cartilage evaluation system, and this system was used to evaluate magnetic resonance imaging (MRI) scans of 20 patients with rheumatoid arthritis. Delayed gadolinium-enhanced MRI was performed, and we found that there were significant differences between individuals with normal hips and those with hip osteoarthritis. We successfully applied our hip cartilage evaluation system in clinical settings. In future, we will be applying this system to evaluate a larger population in clinical settings.

Research Products

• [Journal Article] Prevalence and progression of radiographic ossification of the posterior longitudinal ligament and associated factors in the Japanese population : A 3-year follow-up of the ROAD study (2014)
  • Author(s): Yoshimura N, Nagata K, Muraki S, Oka H, Yoshida M, Enyo Y, Kagotani R, Hashizume H, Yamada H, Ishimoto Y, Teraguchi M, Tanaka S, Kawaguchi H, Toyama Y, Nakamura K, Akune T
  • Journal Title: Osteoporos Int Volume: 25 Pages: 1089-98
• [Journal Article] Exercise habits during middle age are associated with lower prevalence of sarcopenia : the ROAD study (2014)
  • Author(s): Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • Journal Title: Osteoporos Int Volume: 25 Pages: 1081-8
• [Journal Article] Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort : The Wakayama Spine Study (2014)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Minamide A, Oka H, Ishimoto Y, Nagata K, Kagotani R, Takiguchi N, Akune T, Kawaguchi H, Nakamura K, Yoshida M
  • Journal Title: Osteoarthritis Cartilage Volume: 22 Pages: 104-10
• [Journal Article] Physical Performance, Bone and Joint Diseases, and Incidence of Falls in Japanese Men and Women : A Longitudinal Cohort Study (2013)
  • Author(s): Muraki S, Akune T, Oka H, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Osteoporos Int Volume: 24 Pages: 459-466
• [Journal Article] Risk factors for falls in a longitudinal population-based cohort study of Japanese men and women : The ROAD Study (2013)
  • Author(s): Muraki S, Akune T, Ishimoto Y, Nagata K, Yoshida M, Tanaka S, Oka H, Kawaguchi H, Nakamura K, Yoshimura N
  • Journal Title: Bone Volume: 52 Pages: 516-23
• [Journal Article] The mid-term efficacy of intra-articular hyaluronic acid injections on joint structure : A nested case-control study (2013)
  • Author(s): Oka H, Akune T, Muraki S, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • Journal Title: Modern Rheum Volume: 23 Pages: 722-8
• [Journal Article] Associations between radiographic lumbar spinal stenosis and clinical symptoms in the general population : The Wakayama Spine Study (2013)
  • Author(s): Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, Takiguchi N, Minamide A, Oka H, Kawaguchi H, Nakamura K, Akune T, Yoshida M
  • Journal Title: Osteoarthritis Cartilage Volume: 21 Pages: 783-8
• [Journal Article] Profiles of vitamin D insufficiency and deficiency in Japanese men and women : Association with biological, environmental, and nutritional factors and coexisting disorders : The ROAD study (2013)
  • Author(s): Yoshimura N, Muraki S, Oka H, Morita M, Yamada H, Tanaka S, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: Osteoporos Int Volume: 24 Pages: 2775-87
• [Journal Article] Incidence and Risk Factors for Radiographic Knee Osteoarthritis and Knee Pain in Japanese Men and Women : a Longitudinal Population-Based Cohort Study (2012)
  • Author(s): Muraki S, Akune T, Oka H, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Arthritis Rheum Volume: 64 Pages: 1447-56
• [Journal Article] The Prevalence of Vertebral Fracture in Asian Men and Women : Comparison between Hong Kong, Thailand, Indonesia and Japan (2012)
  • Author(s): Kwok A, Leung J, Chan A, Au B, Lau E, Yurianto H, Yuktanandana P, Yoshimura N, Muraki S, Oka H, Akune T, Leung P
  • Journal Title: Public Health Volume: 126 Pages: 523-31
• [Journal Article] Incidence and Risk Factors for Radiographic Lumbar Spondylosis and Lower Back Pain in Japanese Men and Women : The ROAD Study (2012)
  • Author(s): Muraki S, Akune T, Oka H, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Osteoarthritis Cartilage Volume: 20 Pages: 712-8
• [Journal Article] Prevalence of cervical cord compression and its association with physical performance in a population-based cohort in Japan : the Wakayama Spine Study (2012)
  • Author(s): Nagata K, Yoshimura N, Muraki S, Hashizume H, Ishimoto Y, Yamada H, Takiguchi N, Nakagawa Y, Oka H, Kawaguchi H, Nakamura K, Akune T, Yoshida M
  • Journal Title: SPINE Volume: 37 Pages: 1892-8
• [Journal Article] Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis : A 3-year follow-up of the ROAD study (2012)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: Osteoarthritis Cartilage Volume: 20 Pages: 1217-26
• [Journal Article] Prevalence of symptomatic lumbar spinal stenosis and its association with physical performance in a population-based cohort in Japan : The Wakayama Spine Study (2012)
  • Author(s): Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, Takiguchi N, Minamide A, Oka H, Kawaguchi H, Nakamura K, Akune T, Yoshida M
  • Journal Title: Osteoarthritis Cartilage Volume: 20 Pages: 1103-8
• [Journal Article] Does mild cognitive impairment affect the occurrence of radiographic knee osteoarthritis? A 3-year follow-up in the ROAD study (2012)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Tanaka S, Akune T
  • Journal Title: BMJ Open Volume: 2:pii Pages: e001520
  • DOI: 10.1136/bmjopen-2012-001520.
• [Journal Article] Capacity of endogenous sex steroids to predict bone loss in Japanese men : Ten-year follow-up of the Taiji Cohort Study (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: J Bone Miner Metab Volume: 29 Pages: 96-102
• [Journal Article] Health-related Quality of Life in Subjects with Low Back Pain and Knee Pain in a Population-Based Cohort Study of Japanese men : The ROAD study (2011)
  • Author(s): Muraki S, Akune T, Oka H, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: SPINE Volume: 36 Pages: 1312-1319
• [Journal Article] Association of knee osteoarthritis with the accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance in Japanese men and women : The ROAD Study (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: J Rheum Volume: 38 Pages: 921-30
• [Journal Article] Changes in serum levels of biochemical markers of bone turnover over 10 years among Japanese men and women : associated factors and birth-cohort effect (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: The Taiji Study. J Bone Miner Metab Volume: 29 Pages: 699-708
• [Journal Article] Association of Occupational Activity with Joint Space Narrowing and Osteophytosis in the Medial Compartment of the Knee : The ROAD study (2011)
  • Author(s): Muraki S, Oka H, Akune T, En-yo Y, Yoshida M, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Osteoarthritis Cartilage Volume: 19 Pages: 840-846
• [Journal Article] Biochemical markers of bone turnover as predictors for occurrence of osteoporosis and osteoporotic fractures in men and women : Ten-year follow-up of the Taiji cohort study (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: Modern Rheum Volume: 21 Pages: 608-20
• [Journal Article] Prevalence of falls and its association with knee osteoarthritis and lumbar spondylosis as well as knee and lower back pain in Japanese men and women (2011)
  • Author(s): Muraki S, Akune T, Oka H, En-yo Y, Yoshida M, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Arthritis Care Res Volume: 63 Pages: 1425-31
• [Journal Article] Independent Association of Joint Space Narrowing and Osteophyte Formation at the Knee with Health-related Quality of Life in Japan : A Cross-sectional Study (2011)
  • Author(s): Muraki S, Oka H, Akune T, En-yo Y, Yoshida M, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Arthritis Rheum Volume: 63 Pages: 3859-3864
• [Journal Article] Association of vitamin D status with knee pain and radiographic knee osteoarthritis (2011)
  • Author(s): Muraki S, Dennison E, Jameson K, Boucher B, Akune T, Yoshimura N, Judge A, Arden N, Javaid K, Cooper C
  • Journal Title: Osteoarthritis Cartilage Volume: 19 Pages: 1301-1306
• [Journal Article] Reference values for hand grip strength, muscle mass, walking time, and one-leg standing time as indices for locomotive syndrome and associated disability : The second survey of the ROAD study (2011)
  • Author(s): Yoshimura N, Oka H, Muraki S, Akune T, Hirabayashi N, Matsuda S, Nojiri T, Hatanaka K, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Kawaguchi H, Nakamura K
  • Journal Title: J Orthop Sci Volume: 16 Pages: 768-77
• [Journal Article] Association of Dietary Intake with Joint Space Narrowing and Osteophytosis at the Knee in Japanese Men and Women : The ROAD Study
  • Author(s): Muraki S, Akune T, En-yo Y, Yoshida M, Tanaka S, Kawaguchi H, Nakamura K, Oka H, Yoshimura N
  • Journal Title: Modern Rheum Volume: (in press)
• [Journal Article] Prevalence, Incidence, and Progression of Lumbar Spondylosis by Gender and Age Strata
  • Author(s): Muraki S, Yoshimura N, Akune T, Sakae Tanaka, Ikuno Takahashi, Saeko Fujiwara
  • Journal Title: Modern Rheum Volume: (in press)
• [Journal Article] Incidence of certified need of care in the long-term care insurance system and its risk factors in the elderly of Japanese population-based cohorts : The ROAD study
  • Author(s): Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Tokimura F, Yoshida H, Suzuki T, Nakamura K, Yoshimura N
  • Journal Title: Geriatr Gerontol Int Volume: (in press)
• [Journal Article] Prevalence of knee pain, lumbar pain and its co-existence in Japanese men and women : The LOCOMO (Longitudinal Cohorts of Motor System Organ) study
  • Author(s): Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Omori G, Sudo A, Nishiwaki Y, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K
  • Journal Title: J Bone Miner Metab Volume: (in press)
• [Journal Article] Association of knee osteoarthritis with onset and resolution of pain and physical functional disability : The ROAD Study
  • Author(s): Muraki S, Akune T, Nagata K, Ishimoto Y, Yoshida M, Tokimura F, Tanaka S, Oka H, Kawaguchi H, Nakamura K, Yoshimura N
  • Journal Title: Modern Rheum Volume: (in press)
• [Journal Article] Association of physical activities of daily living with the incidence of certified need of care in the long-term care insurance system of Japan : the ROAD study
  • Author(s): Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Tokimura F, Yoshida H, Suzuki T, Nakamura K, Yoshimura N
  • Journal Title: J Orthop Sci Volume: (in press)
• [Journal Article] Incidence of disability and its associated factors in Japanese men and women : The Longitudinal Cohorts of Motor System Organ (LOCOMO) study
  • Author(s): Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Nishiwaki Y, Sudo A, Omori G, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K
  • Journal Title: J Bone Miner Metab Volume: (in press)
• [Journal Article] Prevalence of diffuse idiopathic skeletal hyperostosis of the whole spine and its association with knee osteoarthritis : the ROAD study
  • Author(s): Kagotani R, Yoshida M, Muraki S, Oka H, Hashizume H, Yamada H, Enyo Y, Nagata1 K, Ishimoto Y, Teraguchi M, Tanaka S, Nakamura K, Kawaguchi H, Akune T, Yoshimura N
  • Journal Title: J Bone Miner Metab Volume: (in press)
• [Journal Article] The prevalence of cervical myelopathy among subjects with narrow cervical spinal canal in a population-based MRI study : The Wakayama Spine Study
  • Author(s): Nagata K, Yoshimura N, Hashizume H, Muraki S, Ishimoto Y, Yamada H, Takiguchi N, Nakagawa Y, Minamide A, Oka H, Kawaguchi H, Nakamura K, Akune T, Yoshida M
  • Journal Title: Spine J Volume: (in press)
• [Presentation] Prevalence of sarcopenia and its association with exercise habits in middle age and physical performance in the elderly participants of Japanese population-based cohorts : the ROAD study (2013)
  • Author(s): Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura, K, Oka H, Yoshimura N
  • Organizer: IOF regionals
  • Place of Presentation: Hong Kong, China
  • Year and Date: 20131212-15
• [Presentation] Risk Factors for Multiple Falls in Japanese Men and Women : The ROAD Study (2013)
  • Author(s): Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura, K, Oka H, Yoshimura N
  • Organizer: 2nd Joint Meeting of the International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR)
  • Place of Presentation: Kobe, Japan
  • Year and Date: 20130528-0601
• [Presentation] Higher levels of serum 25(OH)D prevents the occurrence of osteoporosis, but deteriorates knee osteoarthritis : The ROAD study (2013)
  • Author(s): Yoshimura N, Muraki S, Oka H, Nakamura K, Tanaka S, Kawaguchi H, Akune T
  • Organizer: IOF
  • Place of Presentation: Rome, Italy
  • Year and Date: 20130417-21
• [Presentation] The Incidence Rate and Risk Factors for Radiographic Knee Osteoarthritis and Knee Pain : The ROAD Study (2013)
  • Author(s): Muraki S, Akune T, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • Organizer: IOF
  • Place of Presentation: Rome, Italy
  • Year and Date: 20130417-21
• [Presentation] Association of diffuse idiopathic skeletal hyperostosis and bone mineral density and marker of bone metabolism : the ROAD study (2013)
  • Author(s): Kagotani R, Muraki S, Oka H, Yoshida M, Hashizume H, Yamada H, Nagata K, Ishimoto Y, Teraguchi M, Tanaka S, Nakamura K, Kawaguchi H, Akune T, Yoshimura N
  • Organizer: IOF
  • Place of Presentation: Rome, Italy
  • Year and Date: 20130417-21
• [Presentation] Mild Cognitive Impairment Increases The Risk of Knee Osteoarthritis : A 3-Year Follow-Up in The ROAD Study (2012)
  • Author(s): Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T
  • Organizer: IOF Regionals - 3rd Asia-Pacific Osteoporosis Meeting
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 20121213-16
• [Presentation] Physical Performance, Bone and Joint Diseases, and Incidence of Falls in Japanese Men and Women : The ROAD Study (2012)
  • Author(s): Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura K, Oka H, Yoshimura N
  • Organizer: 3rd IOF regionals 2012
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 20121200
• [Presentation] ACCUMULATION OF METABOLIC RISK FACTORS RAISES THE RISK OF OCCURRENCE AND PROGRESSION OF KNEE OSTEOARTHRITIS : THE ROAD STUDY (2012)
  • Author(s): Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T
  • Organizer: EULAR 2012
  • Place of Presentation: Berlin, German
  • Year and Date: 20120600
• [Presentation] Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidemia, and impaired glucose intolerance raises the risk of occurrence and progression of knee osteoarthritis : A 3-year follow-up of the ROAD Study (2012)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Organizer: IOF-ECCEO 2012
  • Place of Presentation: Bordeaux, France
  • Year and Date: 20120321-24
• [Presentation] The prevalence of lumbar spinal stenosis using mobile MRI in local inhabitants : The ROAD-MRI study (2012)
  • Author(s): Ishimoto Y, Yamada H, Nagata K, Hashizume H, Takiguchi N, Yoshida M. Muraki S, Oka H, Akune T, Yoshimura N
  • Organizer: AAOS
  • Place of Presentation: San Francisco, USA
  • Year and Date: 20120207-11
• [Presentation] The Prevalence Of Cervical Cord Compression Using Mobile MRI In Local Inhabitants : The Road-MRI Study (2012)
  • Author(s): Nagata K, Hashizume H, Ishimoto Y, Yamada H, Takiguchi N, Yoshida M. Muraki S, Oka H, Akune T, Yoshimura N
  • Organizer: AAOS
  • Place of Presentation: San Francisco, USA
  • Year and Date: 20120207-11
• [Presentation] Prevalence of cervical cord compression and its association with physical performance in a large population-based cohort : The ROAD-MRI Study (2011)
  • Author(s): Nagata K, Hashizume H, Ishimoto Y, Yamada H, Takiguchi N, Yoshida M. Muraki S, Oka H, Akune T, Yoshimura N
  • Organizer: CSRS
  • Place of Presentation: Arizona, USA
  • Year and Date: 20111208-10
• [Presentation] Vitamin D Insufficiency and Occurrence of Osteoporosis and Disability : The ROAD Study (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Organizer: (ASBMR) 33nd Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, USA
  • Year and Date: 20110916-20
• [Presentation] Incidence of Multiple Falls and Risk Factors in a Longitudinal Population-Based Cohort Study in Japan : The ROAD Study (2011)
  • Author(s): Muraki S, Akune T, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: (ASBMR) 33nd Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, USA
  • Year and Date: 20110916-20
• [Presentation] Incidence and risk factors for radiographic lumbar spondylosis : The ROAD Study (2011)
  • Author(s): Muraki S, Akune T, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: OARSI for the 2011 World Congress on Osteoarthritis
  • Place of Presentation: San Diego, USA
  • Year and Date: 20110916-20
• [Presentation] Risk factors fot the incidence and progress rate of radiographic knee osteoarthritis in Japanese men and women : The ROAD study (2011)
  • Author(s): Muraki S, Akune T, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: OARSI for the 2011 World Congress on Osteoarthritis
  • Place of Presentation: San Diego, USA
  • Year and Date: 20110915-18
• [Presentation] Vitamin D insufficiency and deficiency as a risk factor for fast bone loss among elderly men and women : The ROAD study (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Organizer: 2nd Asia-Pacific Osteoporosis and Bone Meeting
  • Place of Presentation: Gold Coast, Australia
  • Year and Date: 20110904-08
• [Presentation] Risk Factors for Multiple Falls in a Longitudinal Population-Based Cohort Study in Japan : The ROAD Study (2011)
  • Author(s): Muraki S, Akune T, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: 2nd Asia-Pacific Osteoporosis and Bone Meeting
  • Place of Presentation: Gold Coast, Australia
  • Year and Date: 20110904-08
• [Presentation] Role of neuromuscular function in predicting the occurrence of disability : The ROAD study (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Organizer: IEA World Congress of Epidemiology
  • Place of Presentation: Edinburgh, Scotland
  • Year and Date: 20110807-11
• [Presentation] Association between lumbar spinal stenosis and physical performance in a population-based cohort in Japan : The Wakayama Spine Study (2011)
  • Author(s): Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, Takiguchi N, Minamide A, Oka H, Kawaguchi H, Nakamura K, Akune T, Yoshida M
  • Organizer: ISSLS
  • Place of Presentation: Gothenburg, Sweden
  • Year and Date: 20110614-18