2013 Fiscal Year Final Research Report
Development of molecular probe for imaging of malaria infection
| Project/Area Number |
23659590
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAKAYAMA MORIO 長崎大学, 医歯(薬)学総合研究科, 教授 (60164373)
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| Co-Investigator(Kenkyū-buntansha) |
FUCHIGAMI Takeshi 長崎大学, 大学院医歯薬学総合研究科, 准教授 (30432206)
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| Project Period (FY) |
2011 – 2013
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| Keywords | マラリア原虫 / 感染症分子イメージング / 抗マラリア薬 / キナクリン / アミロイド / 放射性ヨウ素標識化合物 |
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| Research Abstract |
We started to develop the molecular probe for imaging of malaria infection which is the most important worldwide infection and advanced the synthesis of the candidates molecular probe based on the fundamental skeleton of antimalarial drugs or the compound which shows an affinity to amyloid. It succeeded in synthesis of the radioactive-iodine labeled quinacrine as antimalarial-drugs, the acridine derivatives which is a fundamental skeleton of quinacrine and its radioactive-iodine labeled compound, and the styrylchromone derivatives which shows an affinity for amyloid and its radioactive-iodine labeled derivatives.However,the direct labeling of the malaria parasite outside a body is not completed.
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[Journal Article] Developmentand Evaluation of a Novel 99mTc-LabeledAnnexin A5 for Early Detection of Response to Chemotherapy2013
Author(s)
Kazuma Ogawa, Katsuichi Ohtsuki, Tomomi Shibata, Miho Aoki, Morio Nakayama, Yoji Kitamura, Masahiro Ono, Masashi Ueda, Tomoki Doue, Masahisa Onoguchi, Kazuhiro Shiba, Akira Odani
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Journal Title
PLOS ONE
Volume: 8
Pages: e81191
DOI
Peer Reviewed
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