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2013 Fiscal Year Final Research Report

Screening of radio-sensitizing phytochemicals and examination on their structures

Research Project

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Project/Area Number 23659593
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionIbaraki Prefectural University of Health Science

Principal Investigator

OHNISHI Ken  茨城県立医療大学, 保健医療学部, 教授 (50152195)

Co-Investigator(Kenkyū-buntansha) HATANO Osamu  奈良県立医科大学, 医学部, 講師 (40164850)
Project Period (FY) 2011 – 2013
Keywords放射線増感 / フィトケミカル / フラボノイド
Research Abstract

We performed screening of about 40 kinds of flavonoid to find novel radiosensitizers derived from plants. From the screening, we found that 2 kinds of flavonoid enhance radiosensitivity of cancer cells and one of the flavonoids (Flavonoid A) has a stronger radiosensitization action to cancer cells compared with normal cells. Furthermore, it is suggested that apoptosis contributes to the radiosensitization. These results show that Flavonoid A is an efficacious radiosensitizer because of its faint cytotoxicity and preferential radiosensitization to cancer cells.

  • Research Products

    (24 results)

All 2014 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (16 results) Remarks (1 results)

  • [Journal Article] Radiosensitization of human lung cancer cells by the novel purine scaffold Hsp90 inhibitor PI-H712014

    • Author(s)
      Segawa T, Fujii Y, Tanaka A, Bando S, Okayasu R, Ohnishi K, Kubota N
    • Journal Title

      International Journal of Molecular Medicine

      Volume: 33 Pages: 559-564

    • Peer Reviewed
  • [Journal Article] 植物由来天然生理活性物質フィトケミカルの放射線増感作用2012

    • Author(s)
      坂東真一, 秦野修, 窪田宜夫, 大西健
    • Journal Title

      放射線生物研究

      Volume: 47 Pages: 193-210

    • Peer Reviewed
  • [Journal Article] Benzyl isothiocyanate sensitizes human pancreatic cancer cells to radiation by inducing apoptosis2011

    • Author(s)
      Ohara M, Kimura S, Tanaka A, Ohnishi K, Okayasu R. and Kubota N
    • Journal Title

      International Journal of Molecular Medicine

      Volume: 28 Pages: 1043-1047

    • Peer Reviewed
  • [Journal Article] Induction of multinucleation in oral squamous cell carcinoma tissue with mutated p53 surviving boron neutron capture therapy2011

    • Author(s)
      Fujita Y, Yamamoto N, Kato I, Iwai S, Ono K, Sakurai Y, Ohnishi K, Ohnishi T, Yura Y
    • Journal Title

      International Journal of Radiation Biology

      Volume: 87 Pages: 293-301

    • Peer Reviewed
  • [Journal Article] siRNA Targeted for NBS1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells2011

    • Author(s)
      Okamoto N, Takahaski A, Ota I, Ohnishi K, Mori E, Kondo N, Noda T, Nakagawa Y, Uemura H, Yane K, Hosoi H, Ohnishi T
    • Journal Title

      International Journal of Hyperthermia

      Volume: 27 Pages: 297-304

    • Peer Reviewed
  • [Journal Article] Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage2011

    • Author(s)
      Noda T, Takahashi A, Kondo N, Mori E, Okamoto N, Nakagawa Y, Ohnishi K, Zdzienicka, MZ, Thompson LH, Helleday T, Asada H, Ohnishi T
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 404 Pages: 206-210

    • Peer Reviewed
  • [Journal Article] Plastic induction of CD133AC133-positive cells in the microenvironment of glioblastoma spheroid

    • Author(s)
      Ohnishi K, Tani T, Bando S, Kubota N, Fujii Y, Hatano O, Harada H
    • Journal Title

      International Journal of Oncology

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] ヒト由来細胞とネコ由来細胞の放射線感受性の違い2014

    • Author(s)
      藤井義大, 坂東真一, 大西健, 加藤宝光
    • Organizer
      茨城大学理学部公開シンポジウム第7回Quantum Medicine 研究会
    • Place of Presentation
      水戸
    • Year and Date
      20140300
  • [Presentation] スフェロイドに出現するCD133 陽性細胞の放射線感受性2014

    • Author(s)
      大西健, 谷俊明, 坂東真一, 藤井義大,窪田宜夫, 秦野修
    • Organizer
      第16回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良
    • Year and Date
      20140200
  • [Presentation] スフェロイドの低酸素微小環境に依存したCD133 発現の可塑的変化2013

    • Author(s)
      谷俊明, 坂東真一, 藤井義大, 窪田宜夫,秦野修, 大西健
    • Organizer
      第11回がんとハイポキシア研究会
    • Place of Presentation
      仙台
    • Year and Date
      20131200
  • [Presentation] グリオブラストーマスフェロイド内低酸素微小環境とCD133陽性細胞の誘導2013

    • Author(s)
      大西健, 谷俊明, 坂東真一, 秦野修, 藤井義大, 窪田宜夫
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      20131000
  • [Presentation] 神経膠芽腫細胞T98Gの単層培養⇔スフェロイド培養間で見られるCD133 陽性細胞の可塑的な誘導2013

    • Author(s)
      大西健, 谷俊明, 坂東真一, 藤井義大,窪田宜夫, 秦野修
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      青森
    • Year and Date
      20131000
  • [Presentation] スフェロイドを用いたCD133 陽性細胞の解析2013

    • Author(s)
      大西健,坂東真一,窪田宜夫,秦野修,谷俊明
    • Organizer
      第15回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良
    • Year and Date
      20130200
  • [Presentation] フラボノイド3 ' ,5,7-Trihydroxy-3,4 '-Dimethoxyflavone に新規に見出されたがん細胞優位な細胞致死作用2012

    • Author(s)
      大西健,坂東真一,秦野修,竹森洋,窪田宜夫
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      20120900
  • [Presentation] 植物由来フラボノイドA に新規に見出されたがん細胞優位な放射線増感作用2012

    • Author(s)
      坂東真一,秦野修,竹森洋,窪田宜夫,大西健
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      20120900
  • [Presentation] フラボノイドA に新規に見出された放射線増感の作用機序2012

    • Author(s)
      坂東真一,秦野修,竹森洋,窪田宜夫,大西健
    • Organizer
      日本放射線影響学会 第55回大会
    • Place of Presentation
      仙台
    • Year and Date
      20120900
  • [Presentation] Screening of phytochemicals sensitizing heat sensitivity of cancer cells2012

    • Author(s)
      Bando S, Hatano O,Takemori H,Kubota N,Ohnishi K
    • Organizer
      The 11th International Congress of Hyperthermic Oncology & The 29 th Japanese Congress of Thermal Medicine (ICHO&JCTM 2012)
    • Place of Presentation
      京都
    • Year and Date
      20120800
  • [Presentation] 新規Hsp90阻害剤PU-H71 のDNA 二重鎖切断修復抑制による放射線増感2012

    • Author(s)
      瀬川達矢,田中彩,坂東真一,松本孔貴,岡安隆一,大西健,窪田宜夫
    • Organizer
      第50回日本放射線腫瘍学会 生物部会学術大会
    • Place of Presentation
      宜野湾
    • Year and Date
      20120600
  • [Presentation] 新規Hsp90 阻害剤PU-H71 の放射線増感メカニズムについて2012

    • Author(s)
      瀬川達矢,田中彩, 坂東真一, 大西健,窪田宜夫
    • Organizer
      第14回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良
    • Year and Date
      20120200
  • [Presentation] フラボノイドTHDF に新規に見出されたがん細胞優位な細胞致死作用2012

    • Author(s)
      坂東真一, 秦野修, 竹森洋, 窪田宜夫,大西健
    • Organizer
      第14回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良
    • Year and Date
      20120200
  • [Presentation] Hsp90 阻害剤Celastrol のヒト腫瘍細胞の放射線増感とp53 status2011

    • Author(s)
      瀬川達矢, 田中彩, 坂東真一, 大西健,窪田宜夫
    • Organizer
      日本放射線腫瘍学会第24回大会
    • Place of Presentation
      神戸
    • Year and Date
      20111100
  • [Presentation] 植物由来の新規放射線増感物質はがん細胞により強い増感作用を示す2011

    • Author(s)
      坂東真一, 秦野修, 竹森洋, 窪田宜夫,大西健
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      神戸
    • Year and Date
      20111100
  • [Presentation] Screening of flavonoids sensitizing radiation sensitivity of cancer cells2011

    • Author(s)
      Ohnishi K, Bando S, Kubota N, Takemori H, Hatano O
    • Organizer
      14th International Congress of Radiation Research
    • Place of Presentation
      Poland, Warsaw
    • Year and Date
      20110800
  • [Remarks]

    • URL

      http://www.hs.ipu.ac.jp/files/Ohnishi/map_1.htm

URL: 

Published: 2015-06-25  

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