2013 Fiscal Year Final Research Report

Novel angiogenesis inhibitor DBP-maf for cancer therapy

Research Project

Project/Area Number	23659611
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	General surgery
Research Institution	Osaka University
Principal Investigator	MATSUURA Nariaki 大阪大学, 医学(系)研究科(研究院), 教授 (70190402)
Co-Investigator(Kenkyū-buntansha)	MORI Seiji 大阪大学, 大学院医学系研究科, 助教 (90467506)
Co-Investigator(Renkei-kenkyūsha)	HAMADA Yoshinosuke 大阪大学, 大学院医学系研究科, 特任助教 (10362683)
Project Period (FY)	2011 – 2013
Keywords	血管新生 / マクロファージ / がん治療
Research Abstract	DBP-maf (Vitamin D binding protein-macrophage activating factor) showed inhibitory activity for angiogenesis through suppressive effect on endothelial proliferation, adhesion activity to extracellular matrix proteins, migration capacity, and tube formation. DBP-maf inhibits markedly angiogenesis by Aorta ring assay, Das assay and Matrigel plague assay. Furthermore DBP-maf has stimulatory effect on macrophage activation. DBP-maf suppresses growth of hepatocellular carcinoma or pancreatic carcinoma cell lines in vivo.