Endocrine therapy for Estrogen receptorβ-positive Triple-negative breast cancer

2012 Fiscal Year Final Research Report

• Project/Area Number: 23659624
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Kyoto University
• Principal Investigator: SAJI Shigehira 京都大学, 医学(系)研究科(研究院), 准教授 (80446567)
• Co-Investigator(Renkei-kenkyūsha): HONMA Naoko 東京都健康長寿医療センター研究所, 研究員 (70321875)
• Project Period (FY): 2011 – 2012
• Keywords: エストロゲン受容体 / 乳がん / ホルモン療法 / タモキシフェン

Research Abstract

Estrogen Receptor (ER) α -negative, Progesterone Receptor(PR)-negative and Her2-negative breast cancer has been known as Triple-negative breast cancer (TNBC), and has poor prognosis. Subset of TNBC express second ER named ERβ, and we reported that these patients might have benefit from tamoxifen treatment. Here we showed that ERβ-nagative TNBC might have unfavorable effect from tamoxifen, and androgen receptor expression and serum concentration of androgen metabolite seemed to have important role in the ERβ-positive TNBC. Further studies including these factors would be warranted for the future clinical trial of this strategy.

Research Products

• [Journal Article] 乳がんの治療 薬物療法 ホルモン療法の治療戦略 (2013)
  • Author(s): 光藤悠子、佐治重衡
  • Journal Title: からだの科学-乳癌のすべて Volume: 277巻 Pages: 67-71
• [Journal Article] Clinical importance of androgen receptor in breast cancer patients treated with adjuvant tamoxifen monotherapy. (2012)
  • Author(s): Honma N, Horii R, Iwase T, Saji S, Younes M, Ito Y, Akiyama F
  • Journal Title: Breast Cancer
  • DOI: DOI:10.1007/s12282-013-0455-5
  • Peer Reviewed
• [Journal Article] Impact ofbody mass index on breast cancer inaccordance with the life-stage of women (2012)
  • Author(s): Suzuki R, Saji S, Toi M.
  • Journal Title: Front Oncol Volume: 2 Pages: 123
  • DOI: DOI:10.3389/fonc.2012.00123
  • Peer Reviewed
• [Journal Article] Fuel and electricity, ER and HER2: a hybrid-car model of breast cancer(Correspondence). (2012)
  • Author(s): Saji S, Sato F, Ueno NT
  • Journal Title: Nat Rev Clin Oncol Volume: 9(7) Pages: 426
  • DOI: DOI:10.1038/nrclinonc.2012.9-cl
• [Journal Article] Relationship between body mass index and preoperative treatment response to aromatase inhibitor exemestane in postmenopausal patients with primary breast cancer (2012)
  • Author(s): Takada M, Saji S, Masuda N, Kuroi K,Sato N, Takei H, Yamamoto Y, Ohno S,Yamashita H, Hisamatsu K, Aogi K, Iwata H, Ueno T, Sasano H, Toi M
  • Journal Title: The Breast Volume: 21 Pages: 40-45
  • Peer Reviewed
• [Journal Article] Sex Steroid Hormones in Pairs of Tumor and Serum from Breast Cancer Patients and Pathobiological Role of Androstene-3 β 17 β -diol (2011)
  • Author(s): Honma N, Saji S, Hirose M, Horiguchi S-I,Kuroi K, Hayashi S-I, Utsumi T, Harada N
  • Journal Title: Cancer Science Volume: 102(10) Pages: 1848-1854
  • Peer Reviewed
• [Presentation] Factors Affecting Aromatase Inhibitors Responsiveness (2012)
  • Author(s): Saji S
  • Organizer: Korean Surgical International Symposium(KOSIS)2012
  • Place of Presentation: COEX(韓国)
  • Year and Date: 2012-12-01
• [Presentation] Serum concentration of Estrone (E1), not Estradiol (E2), is the independent predictive factor of response to neo-adjuvant exemestane treatment in postmenopausal breast cancer patients:JFMC 34-0601 TR (2012)
  • Author(s): Saji S, Takada M, Honma N, Masuda N, Yamamoto Y, Kuroi K, Yamashita H, Ohno S, Ueno T, Toi M.
  • Organizer: The 37th European Society of Medical Oncology 2012 Congress
  • Place of Presentation: Austria Center Vienna(オーストリア)
  • Year and Date: 2012-10-01
• [Presentation] 進行・再発乳がんをめぐる新しい治療戦略 (2012)
  • Author(s): 佐治重衡、佐藤史顕
  • Organizer: 第71回日本癌学会学術総会(シンポジウム)
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2012-09-20
• [Presentation] 乳癌における estrogen receptor-beta の tamoxifen効果予測性についての検討 (2012)
  • Author(s): 本間尚子、堀井理絵、岩瀬拓士、新井冨生、佐治重衡、伊藤良則、秋山太
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2012-09-19
• [Presentation] 内分泌療法の進歩と今後の役割 (2012)
  • Author(s): 佐治重衡、佐藤史顕
  • Organizer: 第10回日本臨床腫瘍学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2012-07-27
• [Presentation] ホルモン療法が効かないとは?耐性克服へのアプローチ (2011)
  • Author(s): 佐治重衡
  • Organizer: 第49回日本癌治療学会学術集会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-27
• [Presentation] Explore the factors predicting response of endocrine therapy for breast cancer (2011)
  • Author(s): Saji S, Sato F
  • Organizer: The Capital International Cancer Conference (CICC) 2011
  • Place of Presentation: China National Convention Center(中国)
  • Year and Date: 2011-09-23