2012 Fiscal Year Final Research Report
Formation of insulin-producing cells from iPS cells in conjunction with islet transplantation
| Project/Area Number |
23659627
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 移植外科学 / インスリン産生細胞 |
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| Research Abstract |
In this study, we attempted to generate insulin-producing cells from mouse iPS cells by co-transplantation with isolated islets (rat, porcine) beneath the kidney capsule of STZ-diabetic nude mice since islets may serve to provide an appropriate circumstances as “nitch”. As a result, clusters of insulin producing cells were found in tumors at 30 days after transplantation. Currently, the study with the use of iPS cells transfected with transcription factors including Pdx1, Ngn3 and MafA) is under investigation.
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