2012 Fiscal Year Final Research Report
Effective delivery of chemotherapeutic nanoparticles by depletinghost Kupffer cells
| Project/Area Number |
23659635
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ODA Tatsuya 筑波大学, 医学医療系, 教授 (20282353)
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| Project Period (FY) |
2011 – 2012
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| Keywords | がん治療 / ナノ粒子 / マクロファージ / クロドロネートリポソーム / ドラッグデリバリー |
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| Research Abstract |
Although chemotherapeutic nanoparticles would confer various advantages, the majority of administrated nanoparticles are known to be spoiled by the reticuloendothelial system (RES). Intending to more effectively deliver therapeutic nanoparticles to target regions in vivo, host RES, especially Kupffer cells in the liver, have been depleted ahead of drug administration. In conclusion, Kupffer cells depletion by clodronate liposomes enhanced the plasma concentration and antitumor effects of Doxil, and would be widely applicable for various clinical cancer chemotherapies using nanoparticles.
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[Journal Article] Platelet-derived adenosine 5'-triphosphate suppresses activation of human hepatic stellate cell: In vitro study2012
Author(s)
Ikeda N, Murata S, Maruyama T, Tamura T, Nozaki R, Kawasaki T, Fukunaga K, Oda T, Sasaki R, Homma M, Ohkohchi N
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Journal Title
Hepatol Res
Volume: 42
Pages: 91-102
DOI
Peer Reviewed
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